Family history of stroke as an independent predictor of ischemic heart disease in men and stroke in women.

Family history of stroke as an independent predictor of ischemic heart disease in men and stroke in women.
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中风家族史是男性缺血性心脏病和女性中风的独立预测因素。

DOI:
10.1093/oxfordjournals.aje.a114224
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发表时间:
1986
影响因子:
5
通讯作者:
Barrett-Connor,E
Barrett-Connor,E
中科院分区:
医学2区
文献类型:
--
作者:
Khaw,KT;Barrett-Connor,E

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已知的主要心血管危险因素,如年龄、胆固醇、血压、吸烟、糖尿病和心脏病家族史,只能解释一部分心血管疾病。在一项对加州南部兰乔贝尔纳多的1,491名男性和1,924名女性(年龄在50-79岁之间)的中上层白人人群进行的研究中,这些人在1972-1974年基线时没有已知的心血管疾病,平均随访9年,在50-64岁的男性中,任何一级亲属的中风家族史是缺血性心脏病死亡率的独立预测因子(相对危险度= 3.3,p <0.05),在控制上述危险因素后,对50-79岁女性脑卒中死亡率的影响(相对危险度= 2.3,p<0.05)。相反,中风家族史不能预测男性中风死亡率或女性缺血性心脏病死亡率。这些结果表明,中风家族史可作为高风险受试者的标志物,并确定和调查心血管疾病的其他主要遗传或环境决定因素,特别是性别差异。
The major known cardiovascular risk factors, age, cholesterol, blood pressure, cigarette smoking, and diabetes and family history of heart attack, explain only a proportion of cardiovascular disease. In a study of 1,491 men and 1,924 women aged 50–79 years in an upper middle-class Caucasian population in Rancho Bernardo, southern California, who were free of known cardiovascular disease at baseline in 1972–1974 and who were followed for an average of nine years, family history of stroke in any first-degree relative was an independent predictor of ischemic heart disease mortality in men 50–64 years of age (relative risk = 3.3,p<0.05) and of stroke mortality in women 50–79 years of age (relative risk = 2.3, p<0.05) after controlling for all the above risk factors. In contrast, family history of stroke was not predictive of stroke mortality in men or of ischemic heart disease mortality in women. These results suggest that family history of stroke may be used as a marker for high-risk subjects and to identify and investigate other major genetic or environmental determinants for cardiovascular disease, particularly sex differences.
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