The effect of inhaled leukotriene D4, histamine, or antigen on central and peripheral airways of guinea pigs: analysis of bronchograms with an interactive image analysis system.
The effect of inhaled leukotriene D4, histamine, or antigen on central and peripheral airways of guinea pigs: analysis of bronchograms with an interactive image analysis system.
复制标题
吸入白三烯 D4、组胺或抗原对豚鼠中央和外周气道的影响：用交互式图像分析系统分析支气管图。
DOI：
10.1016/0014-2999(87)90275-5
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发表时间：
1987
影响因子：
5
通讯作者：
Y. Maki
中科院分区：
文献类型：
--
作者：
Y. Ashida;M. Nomura;H. Kuriki;Y. Maki
用Zeiss交互式图像分析系统（IBAS）测定豚鼠肺容积和分析气道面积，研究吸入白三烯、组胺或抗原对豚鼠气道的影响。通过超声雾化器吸入LTC 4、LTD 4、LTE 4和组胺引起肺膨胀：LTD 4是最有效的白三烯，并且在摩尔基础上比组胺强100倍。对支气管造影片上大、小支气管和细支气管面积的分析结果表明，LTD-4选择性地缩小周围气道面积。在主动致敏的动物中吸入抗原导致肺膨胀和外周气道面积的选择性减少。抗原吸入引起的过敏性支气管收缩明显抑制AA-861，一种5-脂氧合酶抑制剂，但不显着抑制美托咪胺，抗组胺药。这些观察结果表明LTD 4是豚鼠外周气道的有效收缩剂，并且抗原吸入引起的过敏性支气管收缩可以由LTD 4介导。
The effect on guinea pig airways of the inhalation of leukotrienes, histamine or antigen was investigated by measuring changes in lung volume and analyzing the airway area on bronchograms with the Zeiss interactive image analysis system (IBAS). LTC4, LTD4, LTE4and histamine inhaled through an ultrasonic nebulizer caused inflation of the lung: LTD4was the most potent of the leukotrienes and was 100 times more potent than histamine on a molar basis. The results of analyses of areas of large and small bronchi and bronhioles on the bronchograms indicated that LTD4selectively decreased the area of the peripheral airways. Inhalation of an antigen in actively sensitized animals resulted in inflation of the lung and in a selective decrease in the area of the peripheral airways. Anaphylactic bronchoconstriction provoked by antigen inhalation was clearly inhibited by AA-861, a 5-lipoxygenase inhibitor but not significantly by mepyramine, an antihistamine. These observations indicate that LTD4is a potent constrictor of the peripheral airways in guinea pigs and that the anaphylactic bronchoconstriction provoked by antigen inhalation could be mediated by LTD4in actively sensitized guinea pigs.
DOI：
10.1073/pnas.77.7.4354
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DRAZEN, JM;AUSTEN, KF;COREY, EJ
通讯作者：
COREY, EJ
正常人吸入白三烯 D 后气道收缩。阿司匹林治疗的效力、时程和效果。
DOI：
--
发表时间：
1983
期刊：
JAMA
影响因子：
--
作者：
Weiss,JW;Drazen,JM;McFaddenJr,ER;Weller,P;Corey,EJ;Lewis,RA;Austen,KF
通讯作者：
Austen,KF
白三烯 C 对人体的支气管收缩作用。
DOI：
10.1126/science.7063880
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Weiss,JW;Drazen,JM;Coles,N;McFaddenJr,ER;Weller,PF;Corey,EJ;Lewis,RA;Austen,KF
通讯作者：
Austen,KF