CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.
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众所周知，CD 4 + T辅助细胞在体内细胞毒性CD 8 + T淋巴细胞（CTL）应答的引发过程中提供关键信号。T辅助是产生初级CTL应答以及促进保护性CD 8+记忆T细胞发育所必需的。然而，CD 4在效应阶段控制CTL应答中的作用尚不清楚。在这里，我们表明，完全帮助效应CTL本身并不能自给自足地进入感染组织，而是依赖于CD 4 + T细胞提供必要的线索。CD 4+辅助性T细胞通过分泌IFN-γ和诱导感染组织中局部趋化因子的分泌来间接控制CTL的迁移。我们的研究结果揭示了CD 4在动员效应细胞毒性T淋巴细胞到感染的外周部位帮助消除感染细胞方面的一个以前未被重视的作用。
CD4+ T helper cells are well known for their role in providing critical signals during priming of cytotoxic CD8+ T lymphocyte (CTL) responses in vivo. T help is required for the generation of primary CTL responses as well as in promoting protective CD8+ memory T cell development. However, the role of CD4 help in the control of CTL responses at the effector stage is unknown. Here, we show that fully helped effector CTLs are not themselves self-sufficient for entry into the infected tissue, but rely on the CD4+ T cells to provide the necessary cue. CD4+ T helper cells control the migration of CTL indirectly through the secretion of IFN-γ and induction of local chemokine secretion in the infected tissue. Our results reveal a previously unappreciated role of CD4 help in mobilizing effector CTL to the peripheral sites of infection where they help to eliminate infected cells.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
DOI：
10.1084/jem.20082039
发表时间：
2008-12-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Iijima N;Linehan MM;Zamora M;Butkus D;Dunn R;Kehry MR;Laufer TM;Iwasaki A
通讯作者：
Iwasaki A
影响因子：
3.7
作者：
Milligan, GN;Bernstein, DI
通讯作者：
Bernstein, DI
影响因子：
30.5
作者：
Reboldi, Andrea;Coisne, Caroline;Sallusto, Federica
通讯作者：
Sallusto, Federica
DOI：
10.1073/pnas.0707179104
发表时间：
2007-11-27
影响因子：
11.1
作者：
Iijima, Norifumi;Linehan, Melissa M.;Iwasaki, Akiko
通讯作者：
Iwasaki, Akiko