Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins.
Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins.
复制标题
DOI：
10.3389/fonc.2021.761107
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Zhu PF;Wang MX;Chen ZL;Yang L
他汀类药物作为降脂药物广泛应用于临床，已被证明对心血管、内分泌、代谢综合征等疾病的治疗有效。最新的临床前证据显示，他汀类药物对肿瘤细胞具有抗增殖、促凋亡、抗侵袭和放疗增敏作用，提示他汀类药物有可能成为一种新型的抗肿瘤药物。长期以来，甲羟戊酸通路被证明在肿瘤细胞的发生发展中起着支持作用。他汀类药物作为一种有效的甲羟戊酸途径抑制剂，在大量研究中被证明具有直接的辅助抗肿瘤作用。此外，他汀类药物通过铁凋亡、焦凋亡、自噬和肿瘤微环境（TME）发挥抗肿瘤作用也逐渐被发现。然而，他汀类药物在肿瘤微环境中的抗肿瘤作用的具体机制尚未明确阐明。本文从缺氧微环境、免疫微环境、代谢微环境、酸性微环境和机械微环境等方面综述了他汀类药物在肿瘤微环境中的抗肿瘤作用。
Statins is widely used in clinical practice as lipid-lowering drugs and has been proven to be effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other diseases. The latest preclinical evidence shows that statins have anti-proliferation, pro-apoptotic, anti-invasion and radiotherapy sensitization effects on tumor cells, suggesting that statins may become a new type of anti-tumor drugs. For a long time, mevalonate pathway has been proved to play a supporting role in the development of tumor cells. As an effective inhibitor of mevalonate pathway, statins have been proved to have a direct auxiliary anti-tumor effect in a large number of studies. In addition, anti-tumor effects of statins through ferroptosis, pyroptosis, autophagy and tumor microenvironment (TME) have also been gradually discovered. However, the specific mechanism of the antitumor effect of statins in the tumor microenvironment has not been clearly elucidated. Herein, we reviewed the antitumor effects of statins in tumor microenvironment, focusing on hypoxia microenvironment, immune microenvironment, metabolic microenvironment, acid microenvironment and mechanical microenvironment.
登录
查看更多内容
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
5.6
作者：
Cruz PM;Mo H;McConathy WJ;Sabnis N;Lacko AG
通讯作者：
Lacko AG
瑞舒伐他汀通过抑制 NLRP3 炎性体激活来预防冠状动脉微栓塞引起的心脏损伤
影响因子：
9
作者：
Chen A;Chen Z;Zhou Y;Wu Y;Xia Y;Lu D;Fan M;Li S;Chen J;Sun A;Zou Y;Qian J;Ge J
通讯作者：
Ge J
DOI：
10.1186/s40880-018-0301-4
发表时间：
2018-05-21
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
Cheng C;Geng F;Cheng X;Guo D
通讯作者：
Guo D
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M