Review Article: Cystic Degeneration/Spongiosis Hepatis in Rats
Review Article: Cystic Degeneration/Spongiosis Hepatis in Rats
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评论文章：大鼠囊性变/海绵状肝炎
DOI：
10.1080/019262302753559551
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发表时间：
2002
影响因子：
1.5
通讯作者：
R. Kerlin
中科院分区：
文献类型：
--
作者：
E. Karbe;R. Kerlin
Cystic degeneration/spongiosis hepatis in rats has been proposed to be a preneoplastic and/or neoplastic lesion by some authors, because of its proliferative properties and persistent increased cell turnover rate in stop experiments using hepatocarcinogens , and the assumption that it can develop into a sarcoma. The neoplastic potential of cystic degeneration is questioned in this review article. Cystic degeneration, which appears to derive from altered Ito cells, does not have neoplastic histomorphologi c characteristics, although it may be composed of cells with an increased mitotic index. In this regard, persistent proliferation is also seen with other nonneoplastic lesions. Arguments are presented to show that the induced, probably extremely rare sarcoma that was associated with cystic degeneration most likely derives from the very rare induced spherical Ito-cell aggregate with an unusually high cellular turnover rate in rats treated with hepatocarcinogens , and not from cystic degeneration. Also, in none of 12 referenced standard oncogenicity studies with chemically induced cystic degeneration was the lesion associated with mesenchymal (Ito-cell) tumors. Consequently, evidence is lacking that cystic degeneration in rats should be classifi ed as a preneoplastic or neoplastic lesion. The 12 oncogenicity studies in rats with induced cystic degeneration showed a marked sex predilection, with males more likely to develop either spontaneous or chemically induced lesions. In these 12 studies, cystic degeneration was more often associated with hepatocellular hypertrophy or hepatotoxicity, rather than hepatocarcinogenicity. Thus, it is concluded that hepatocarcinogens induce cystic degeneration, not because they are carcinogenic, but because they have other effects on the liver, and that cystic degeneration may be a secondary/reparative change. Cystic degeneration in fi sh parallels the situation in rats in many respects, yet the existence of the lesion in other species, including man, is not as well supported. Based on the data presented in this review, spontaneous and induced cystic degeneration in rats and fi sh is not a preneoplastic or neoplastic lesion and risk assessment for man can be based on no-effect levels and safety margins, as for other nonneoplasti c adverse effects that have no counterpart in man.
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DOI：
--
发表时间：
1992-04
期刊：
Journal of submicroscopic cytology and pathology
影响因子：
--
作者：
D. Rockey;J. Boyles;G. Gabbiani;S. Friedman
通讯作者：
D. Rockey;J. Boyles;G. Gabbiani;S. Friedman
影响因子：
29.4
作者：
Marra, F;Gentilini, A;Gentilini, P
通讯作者：
Gentilini, P
肽生长因子对肝脏脂肪储存细胞中巨噬细胞集落刺激因子的调节。
DOI：
10.1152/ajpcell.1992.262.4.c876
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Pinzani,M;Abboud,HE;Gesualdo,L;Abboud,SL
通讯作者：
Abboud,SL
层粘连蛋白在正常大鼠肝脏中的免疫定位以及原代培养物中肝脂肪细胞的层粘连蛋白的生物合成。
影响因子：
29.4
作者：
Maher,JJ;Friedman,SL;Roll,FJ;Bissell,DM
通讯作者：
Bissell,DM
影响因子：
1.8
作者：
Davis, EG;Sang, YM;Blecha, F
通讯作者：
Blecha, F