Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study.
Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study.
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北方城市汉族人群非酒精性脂肪肝对代谢综合征的预测：一项前瞻性队列研究
DOI：
10.1371/journal.pone.0096651
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xue F
中科院分区：
文献类型：
--
作者：
Zhang T;Zhang Y;Zhang C;Tang F;Li H;Zhang Q;Lin H;Wu S;Liu Y;Xue F
目的探讨非酒精性脂肪性肝病（NAFLD）与代谢综合征（MetS）的关系，并评价NAFLD作为预测代谢综合征（MetS）危险性的指标在北方城市汉族人群中的价值。材料和方法在2005年至2011年期间，共有17，920名基线时无MetS的队列成员被纳入本研究。根据基线时的NAFLD状态、随访后的MetS状态比较队列的基线特征。使用考克斯比例风险模型估计基线时NAFLD的未校正或校正的风险比（HR），预测MetS的风险。结果2005 - 2011年新发代谢综合征2,183例，占12.18%。在未校正模型中，NAFLD预测MetS的HR（95%CI）为3.65（3.35，3.97）。调整年龄、性别、代谢因素、吸烟和运动等混杂因素后，HR（95%CI）为1.70（1.55，1.87）。NAFLD预测代谢综合征的校正HR（95% CI）女性为2.06（1.72，2.46），男性为1.55（1.39，1.72）。此外，163名参与者在基线时没有任何MetS成分的参与者中发展了MetS，其调整后的HR仍然显著，为1.87（1.12，3.13）。结论NAFLD是预测北方城市汉族人群MetS发生的独立危险因素，NAFLD患者应积极控制体重和饮食，预防MetS的发生。
Objectives To explore the relationship between non-alcoholic fatty liver disease (NAFLD) and the metabolic syndrome (MetS), and evaluate the value of NAFLD as a marker for predicting the risk of MetS in a large scale prospective cohort from northern urban Han Chinese population. Materials and Methods A total of 17,920 MetS-free at baseline cohort members was included in the current study between 2005 and 2011. The baseline characteristics of the cohort were compared by NAFLD status at baseline, MetS status after follow-up. Cox proportional hazards models were used to estimate the unadjusted or adjusted hazard ratios (HRs) for NAFLD at baseline predicting the risk of MetS. Results 2,183 (12.18%) new cases of MetS occurred between 2005 and 2011. In unadjusted model, HRs (95% CIs) for NAFLD predicting MetS was 3.65 (3.35, 3.97). After adjusting the confounding factors of age, gender, the metabolic factors, smoke and exercise, the HRs (95% CIs) was 1.70 (1.55, 1.87). Gender difference was observed, adjusted HRs (95% CIs) of NAFLD for predicting MetS were 2.06(1.72, 2.46) and 1.55(1.39, 1.72) in female and male population, respectively. Moreover, 163 participants developed MetS among participants without any MetS component at baseline, and its adjusted HRs was still significant, 1.87 (1.12, 3.13). Conclusion The present study indicates that NAFLD is an independent risk factor for predicting the risk of MetS in northern urban Han Chinese population, and the people with NAFLD should initiate weight and dietary control to prevent the occurrence of MetS.
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DOI：
10.1111/j.1440-1746.2005.04058.x
发表时间：
2005-12-01
影响因子：
4.1
作者：
Fan, JG;Zhu, JN;Chen, SY
通讯作者：
Chen, SY
影响因子：
7.7
作者：
Marchesini, G;Brizi, M;Melchionda, N
通讯作者：
Melchionda, N
影响因子：
25.7
作者：
Fan, JG;Zhu, J;Chen, SY
通讯作者：
Chen, SY
影响因子：
5.1
作者：
Mohan, V.;Farooq, S.;Pitchumoni, C. S.
通讯作者：
Pitchumoni, C. S.
影响因子：
9.8
作者：
Kwon, Young-Min;Oh, Seung-Won;Chung, Goh Eun
通讯作者：
Chung, Goh Eun