Neural Mechanisms of Negative Symptoms
Neural Mechanisms of Negative Symptoms
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阴性症状的神经机制
DOI：
10.1192/s0007125000291599
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发表时间：
1989
影响因子：
10.5
通讯作者：
N. Andreasen
中科院分区：
文献类型：
--
作者：
N. Andreasen
When Kraepelin originally defined and described dementia praecox, he assumed that it was due to some type of neural mechanism. He hypothesised that abnormalities could occur in a variety of brain regions, including the prefrontal, auditory, and language regions of the cortex. Many members of his department, including Alzheimer and Nissl, were actively involved in the search for the neuropathological lesions that would characterise schizophrenia. Although Kraepelin did not use the term ‘negative symptoms', he describes them comprehensively and states explicitly that he believes the symptoms of schizophrenia can be explained in terms of brain dysfunction: “If it should be confirmed that the disease attacks by preference the frontal areas of the brain, the central convolutions and central lobes, this distribution would in a certain measure agree with our present views about the site of the psychic mechanisms which are principally injured by the disease. On various grounds, it is easy to believe that the frontal cortex, which is specially well developed in man, stands in closer relation to his higher intellectual abilities, and these are the faculties which in our patients invariably suffer profound loss in contrast to memory and acquired ability.” Kraepelin (1919, p. 219)
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活人大脑中神经递质受体的成像。
影响因子：
--
作者：
Sedvall,G;Farde,L;Persson,A;Wiesel,FA
通讯作者：
Wiesel,FA
精神分裂症额叶系统的结构异常。
影响因子：
--
作者：
Andreasen,N;Nasrallah,HA;Dunn,V;Olson,SC;Grove,WM;Ehrhardt,JC;Coffman,JA;Crossett,JH
通讯作者：
Crossett,JH
影响因子：
21.1
作者：
M. Bannon;R. Roth
通讯作者：
M. Bannon;R. Roth
精神分裂症的心室扩大：定义和患病率。
DOI：
10.1176/ajp.139.3.292
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen,NC;Smith,MR;Jacoby,CG;Dennert,JW;Olsen,SA
通讯作者：
Olsen,SA
影响因子：
--
作者：
Gur,RE;Gur,RC;Skolnick,BE;Caroff,S;Obrist,WD;Resnick,S;Reivich,M
通讯作者：
Reivich,M