Indoor residual spraying with a mixture of clothianidin (a neonicotinoid insecticide) and deltamethrin provides improved control and long residual activity against pyrethroid resistant Anopheles gambiae sl in Southern Benin.
Indoor residual spraying with a mixture of clothianidin (a neonicotinoid insecticide) and deltamethrin provides improved control and long residual activity against pyrethroid resistant Anopheles gambiae sl in Southern Benin.
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DOI：
10.1371/journal.pone.0189575
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
N'Guessan R
中科院分区：
文献类型：
--
作者：
Ngufor C;Fongnikin A;Rowland M;N'Guessan R
迫切需要用于室内滞留喷洒的新杀虫剂，这种杀虫剂可以改善和延长对已对现有杀虫剂产生抗药性的疟疾媒介的控制。新烟碱是一种新的化学物质，它代表着一类新的公共卫生化学。氯硫醚是烟碱型乙酰胆碱受体的激动剂。使用氯硫氰胺和世界卫生组织批准的另一种杀虫剂，如溴氰菊酯的混合物，可改善对抗药性疟疾媒介种群的控制，并可作为管理抗药性的工具。评价了一种新型溴氰菊酯和氯氰菊酯的红外光谱混剂对野生拟除虫菊酯抗性按蚊的药效和残留活性。贝宁湾实验小屋里的冈比亚吸虫。对混剂的两种施用量进行了试验，并与氯氰菊酯和溴氰菊酯单独使用进行了比较。为了评估在不同局部墙基上处理的残留效果，实验小屋的内墙被水泥、泥浆或胶合板覆盖。Clothianidin在野生拟除虫菊酯抗性按蚊的死亡率中有明显的延迟表达。冈比亚原虫在实验小屋中，暴露120小时后达到完全效果。在为期12个月的小屋试验中，对照小屋的总死亡率为15%，溴氰菊酯处理小屋的死亡率为24-29%。氯硫氰菊酯200 mg/m~2与溴氰菊酯25 mg/m~2的混配可导致较高的幼虫死亡率(在泥墙上为87%，在水泥墙上为82%，在木墙上为61%)，主要是由于氯硫氰菊酯的成分和高的出苗率(67-76%)，主要是由于溴氰菊酯的成分。在泥土和水泥墙上8-9个月的死亡率保持在80%。实验室敏感蚊虫的每月原位锥体生物测定结果证实了残留活性的趋势。冈比亚基苏木品系。使用氯硫氰菊素和溴氰菊酯混合物的IRS宣传活动有可能长期控制由抗拟除虫菊酯蚊子种群传播的疟疾。
There is an urgent need for new insecticides for indoor residual spraying (IRS) which can provide improved and prolonged control of malaria vectors that have developed resistance to existing insecticides. The neonicotinoid, clothianidin represents a class of chemistry new to public health. Clothianidin acts as an agonist on nicotinic acetyl choline receptors. IRS with a mixture of Clothianidin and another WHO approved insecticide such as deltamethrin could provide improved control of insecticide resistant malaria vector populations and serve as a tool for insecticide resistance management. The efficacy and residual activity of a novel IRS mixture of deltamethrin and clothianidin was evaluated against wild pyrethroid resistant An. gambiae sl in experimental huts in Cove, Benin. Two application rates of the mixture were tested and comparison was made with clothianidin and deltamethrin applied alone. To assess the residual efficacy of the treatments on different local wall substrates, the inner walls of the experimental huts were covered with either cement, mud or plywood. Clothianidin demonstrated a clear delayed expression in mortality of wild pyrethroid resistant An. gambiae sl in the experimental huts which reached its full effect 120 hours after exposure. Overall mortality over the 12-month hut trial was 15% in the control hut and 24–29% in the deltamethrin-treated huts. The mixture of clothianidin 200mg/m2 and deltamethrin 25mg/m2 induced high overall hut mortality rates (87% on mud walls, 82% on cement walls and 61% on wooden walls) largely due to the clothianidin component and high hut exiting rates (67–76%) mostly due to the deltamethrin component. Mortality rates remained >80% for 8–9 months on mud and cement walls. The residual activity trend was confirmed by results from monthly in situ cone bioassays with laboratory susceptible An. gambiae Kisumu strain. IRS campaigns with the mixture of clothianidin plus deltamethrin have the potential to provide prolonged control of malaria transmitted by pyrethroid resistant mosquito populations.
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影响因子：
3
作者：
Reid MC;McKenzie FE
通讯作者：
McKenzie FE
影响因子：
3
作者：
Etang J;Nwane P;Mbida JA;Piameu M;Manga B;Souop D;Awono-Ambene P
通讯作者：
Awono-Ambene P
影响因子：
3.7
作者：
N'Guessan R;Odjo A;Ngufor C;Malone D;Rowland M
通讯作者：
Rowland M
影响因子：
6.1
作者：
Tomizawa, M;Lee, DL;Casida, JE
通讯作者：
Casida, JE
影响因子：
3.7
作者：
Ngufor C;Critchley J;Fagbohoun J;N'Guessan R;Todjinou D;Rowland M
通讯作者：
Rowland M