Chlorfenapyr (A Pyrrole Insecticide) Applied Alone or as a Mixture with Alpha-Cypermethrin for Indoor Residual Spraying against Pyrethroid Resistant Anopheles gambiae sl: An Experimental Hut Study in Cove, Benin.
Chlorfenapyr (A Pyrrole Insecticide) Applied Alone or as a Mixture with Alpha-Cypermethrin for Indoor Residual Spraying against Pyrethroid Resistant Anopheles gambiae sl: An Experimental Hut Study in Cove, Benin.
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DOI：
10.1371/journal.pone.0162210
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Rowland M
中科院分区：
文献类型：
--
作者：
Ngufor C;Critchley J;Fagbohoun J;N'Guessan R;Todjinou D;Rowland M
室内向墙壁和天花板喷洒残留杀虫剂仍然是控制疟疾的主要方法。疟疾病媒的杀虫剂耐药性是一个日益严重的问题。迫切需要新型室内滞留喷洒杀虫剂，以改善对拟除虫菊酯耐药疟疾病媒的控制。杀虫剂混合物有可能在某些情况下提高药效，甚至控制耐药性，但这种可能性在实验上仍未得到充分探索。氯虫腈是一种新型吡咯类杀虫剂，已显示出改善对目前世卫组织批准的杀虫剂产生抗药性的蚊子控制的潜力。在贝宁南部Cove试验棚内，评价了氯虫腈单独或与高效氯氰菊酯（一种拟除虫菊酯类杀虫剂）混用本药剂对野生自由飞行的抗药性冈比亚按蚊的杀灭效果，并与单独使用高效氯氰菊酯的药剂进行了比较。每两周进行30分钟的原位锥形生物测定，以评估杀虫剂在处理过的小屋壁上的残留效果。试验期间使用氯菊酯和溴氰菊酯处理过的纸张进行的世卫组织抗性生物测定中，来自Cove hut站点的野生冈比亚蚊的存活率为0.90%。进入实验小屋的自由飞蚊死亡率为4%。高效氯氰菊酯IRS处理的死亡率与对照组无显著差异（5%,P < 0.656）。单独使用氯虫那韦的死亡率最高（63%）。高效氯氰菊酯+氯虫腈混合药剂杀蚊率低于单独使用氯虫腈药剂（43% vs. 63%， P<0.001）。尽管锥体生物测定结果显示，使用氯虫腈后，2周后残留死亡率迅速下降至30%以下，但进入氯虫腈室内的野生自由飞冈比亚蚊两周死亡率一直很高（50-70%），且持续时间较长，可达4个月以上。与拟除虫菊酯类杀虫剂或混合杀虫剂相比，氯虫腈混合杀虫剂显示出显著改善对拟除虫菊酯类杀虫剂抗性地区疟疾传播控制的潜力。30分钟的原位锥生物测定不能预测在现场条件下氯虫腈IRS的性能。
Indoor spraying of walls and ceilings with residual insecticide remains a primary method of malaria control. Insecticide resistance in malaria vectors is a growing problem. Novel insecticides for indoor residual spraying (IRS) which can improve the control of pyrethroid resistant malaria vectors are urgently needed. Insecticide mixtures have the potential to improve efficacy or even to manage resistance in some situations but this possibility remains underexplored experimentally. Chlorfenapyr is a novel pyrrole insecticide which has shown potential to improve the control of mosquitoes which are resistant to current WHO-approved insecticides. The efficacy of IRS with chlorfenapyr applied alone or as a mixture with alpha-cypermeththrin (a pyrethroid) was evaluated in experimental huts in Cove, Southern Benin against wild free flying pyrethroid resistant Anopheles gambiae sl. Comparison was made with IRS with alpha-cypermethrin alone. Fortnightly 30-minute in situ cone bioassays were performed to assess the residual efficacy of the insecticides on the treated hut walls. Survival rates of wild An gambiae from the Cove hut site in WHO resistance bioassays performed during the trial were >90% with permethrin and deltamethrin treated papers. Mortality of free-flying mosquitoes entering the experimental huts was 4% in the control hut. Mortality with alpha-cypermethrin IRS did not differ from the control (5%, P>0.656). The highest mortality was achieved with chlorfenapyr alone (63%). The alpha-cypermethrin + chlorfenapyr mixture killed fewer mosquitoes than chlorfenapyr alone (43% vs. 63%, P<0.001). While the cone bioassays showed a more rapid decline in residual mortality with chlorfenapyr IRS to <30% after only 2 weeks, fortnightly mortality rates of wild free-flying An gambiae entering the chlorfenapyr IRS huts were consistently high (50–70%) and prolonged, lasting over 4 months. IRS with chlorfenapyr shows potential to significantly improve the control of malaria transmission in pyrethroid resistant areas compared to pyrethroid IRS or the mixture. Thirty minute in situ cone bioassays are not predictive of the performance of chlorfenapyr IRS under field conditions.
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影响因子：
11.8
作者：
Edi CV;Koudou BG;Jones CM;Weetman D;Ranson H
通讯作者：
Ranson H
DOI：
10.1016/j.trstmh.2010.07.008
发表时间：
2010-10-01
影响因子：
2.2
作者：
Oxborough, R. M.;Kitau, J.;Rowland, M. W.
通讯作者：
Rowland, M. W.
影响因子：
3.2
作者：
Aikpon, Rock;Agossa, Fiacre;Akogbeto, Martin
通讯作者：
Akogbeto, Martin
乙酰胆碱酯酶（ACE-1）靶位点突变119s在Anopheles Gambiae S.S.中强烈诊断出氨基甲酸酯和有机磷酸盐的耐药性。以及加纳南部的肛门coluzzii。
影响因子：
3
作者：
Essandoh J;Yawson AE;Weetman D
通讯作者：
Weetman D
影响因子：
4.7
作者：
BLACK, BC;HOLLINGWORTH, RM;DONOVAN, S
通讯作者：
DONOVAN, S