Cyclin E deregulation is an early event in the development of breast cancer.
Cyclin E deregulation is an early event in the development of breast cancer.
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DOI：
10.1007/s10549-008-0266-0
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发表时间：
2009-06
影响因子：
3.8
通讯作者：
Bedrosian I
中科院分区：
文献类型：
--
作者：
Shaye A;Sahin A;Hao Q;Hunt K;Keyomarsi K;Bedrosian I
细胞周期蛋白E已被证明在一些人类乳腺癌中过度表达，然而，缺乏数据支持细胞周期蛋白E的解除调控是人类乳腺肿瘤发生的早期事件。我们分析了183例乳腺癌患者的手术标本，并评估了细胞周期蛋白E在浸润性癌、癌旁原位癌(CIS)和非肿瘤性乳腺实质中的表达。细胞周期蛋白E在1/3的浸润性癌组织、1/3的癌旁组织和近一半的癌旁非肿瘤性乳腺上皮细胞中高表达(44%vs.33%，P≤.05)。同一患者乳腺浸润性癌、癌旁组织和非肿瘤性乳腺上皮细胞中细胞周期蛋白E的核标记高度一致(P<；0.0001)。在一小部分肿瘤标本中可见细胞周期蛋白E定位于细胞质。我们的研究结果表明，细胞周期蛋白E的失控是乳腺上皮细胞从组织学上的良性发展到浸润性癌的早期事件，并且通过过度表达和细胞定位的改变而发生。
Cyclin E has been shown to be overexpressed in some human breast cancers, however, data to support deregulation of cyclin E as an early event in human mammary tumor development is lacking. We analyzed surgical specimens from 183 patients with breast carcinomas and evaluated cyclin E expression in areas of invasive carcinoma, adjacent carcinoma in situ (CIS), and non-neoplastic breast parenchyma. Overexpression of cyclin E was seen in one-third of invasive carcinoma samples, one-third of the CIS component and nearly half of the non-neoplastic breast epithelial cells adjacent to carcinoma (44% vs. 33%, P ≤ 0.05). Nuclear labeling for cyclin E was highly concordant between areas of in invasive carcinoma, CIS and non-neoplastic breast epithelial cells from the same patient (P < 0.0001). Localization of cyclin E to the cytoplasm was seen in a small proportion of tumor samples. Our findings suggest that cyclin E deregulation is an early event in the progression from histologically benign mammary epithelial cells to invasive carcinoma and occurs through both overexpression and altered cellular localization.
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影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
影响因子：
3.3
作者：
Moore, JD;Kornbluth, S;Hunt, T
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Hunt, T
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56.9
作者：
KOFF, A;GIORDANO, A;ROBERTS, JM
通讯作者：
ROBERTS, JM
影响因子：
56.9
作者：
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通讯作者：
Ruoslahti, E
影响因子：
11.2
作者：
Akli, Said;Van Pelt, Carolyn S.;Keyomarsi, Khandan
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