Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.
Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.
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DOI：
10.1016/j.ijpara.2008.08.003
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发表时间：
2009-01
影响因子：
4
通讯作者：
Gause WC
中科院分区：
文献类型：
--
作者：
Patel N;Kreider T;Urban JF Jr;Gause WC
感染许多组织寄生的肠道线虫后产生的保护性免疫反应的特征是IL-4和IL-13的升高以及CD4+T细胞、粒细胞和巨噬细胞的数量增加。这些细胞聚集在感染部位，在许多情况下可以介导对这些大型多细胞病原体的抵抗。最近的研究表明，这些免疫细胞群通过它们的差异激活和刺激新效应分子的产生的能力而介导了新的潜在机制。这些新发现的保护机制可能为开发针对这类病原体的免疫疗法和疫苗提供新的策略。在这篇综述中，我们将回顾最近的研究，阐明了宿主对三种广泛使用的组织寄生肠道线虫模型的宿主保护机制：多回螺旋线虫、小鼠旋毛虫和旋毛虫。
The protective immune response that develops following infection with many tissue-dwelling intestinal nematode parasites is characterized by elevations in IL-4 and IL-13 and increased numbers of CD4+ T cells, granulocytes and macrophages. These cells accumulate at the site of infection and in many cases can mediate resistance to these large multicellular pathogens. Recent studies suggest novel potential mechanisms mediated by these immune cell populations through their differential activation and ability to stimulate production of novel effector molecules. These newly discovered protective mechanisms may provide novel strategies to develop immunotherapies and vaccines against this group of pathogens. In this review, we will examine recent studies elucidating mechanisms of host protection against three widely-used experimental murine models of tissue-dwelling intestinal nematode parasites: Heligmosomoides polygyrus, Trichuris muris and Trichinella spiralis.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
影响因子：
5.4
作者：
Dixon, Helen;Blanchard, Carine;Else, Kathryn J.
通讯作者：
Else, Kathryn J.
影响因子：
5.4
作者：
Faulkner, H;Humphreys, N;Grencis, R
通讯作者：
Grencis, R
影响因子：
2.2
作者：
Betts, CJ;Else, KJ
通讯作者：
Else, KJ
影响因子：
30.5
作者：
Denning, Timothy L.;Wang, Yi-Chong;Pulendran, Bali
通讯作者：
Pulendran, Bali