Histological subtype of lung cancer in relation to socio-economic deprivation in South East England.
Histological subtype of lung cancer in relation to socio-economic deprivation in South East England.
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DOI：
10.1186/1471-2407-8-139
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发表时间：
2008-05-19
期刊：
影响因子：
3.8
通讯作者：
Møller H
中科院分区：
文献类型：
--
作者：
Bennett VA;Davies EA;Jack RH;Mak V;Møller H
以前的研究发现，影响男性和女性的肺癌组织学亚型存在差异。我们的目的是调查英格兰东南部地区男性和女性肺癌组织学亚型的发病率与社会经济贫困的关系。1995年至2004年期间，48,031名男性和30,454名女性被诊断患有肺癌的数据来自泰晤士癌症登记数据库。使用欧洲标准人群计算每年组织学亚型的标准化发病率。使用2004年贫困多重指数的收入领域，将2000年至2004年诊断的患者根据其居住地的邮政编码分为五分之一的社会经济贫困。然后计算每个剥夺五分位数的每个组织学亚型的标准化率。Poisson回归模型分别拟合男性和女性的数据，以检验社会经济剥夺与腺癌之间的关系不如其他亚型强的假设。在雄性动物中，除腺癌外，所有特定组织学亚型的发生率均下降。鳞状细胞癌仍然是最常见的特定亚型，大细胞癌最不常见。在女性中，鳞状细胞癌最初是最常见的，但其发病率略有下降，而腺癌的发病率有所增加。在男性和女性中，肺癌的总体年龄标准化发病率随着贫困程度的增加而增加。然而，在男性（p < 0.001）和女性（p = 0.003）中，腺癌的这些趋势不如其他亚型强。男性和女性肺癌组织学亚型的时间趋势和分布与其他西方人群的报告相似。在男性和女性中，腺癌与剥夺的相关性低于其他亚型。这可能是因为它的发展与个人吸烟史的联系不那么紧密。
Previous studies have found differences in the histological subtypes of lung cancers affecting males and females. Our objective was to investigate trends in the incidence of histological subtypes of lung cancer in males and females in relation to socio-economic deprivation in South East England. Data on 48,031 males and 30,454 females diagnosed with lung cancer between 1995 and 2004 were extracted from the Thames Cancer Registry database. Age-standardised incidence rates for histological subtypes were calculated for each year, using the European standard population. Using the Income Domain of the Multiple Index of Deprivation 2004, patients diagnosed between 2000 and 2004 were classified into quintiles of socio-economic deprivation based on their postcode of residence. Age-standardised rates for each histological subtype were then calculated for each deprivation quintile. A Poisson regression model was fitted to the data for males and females separately to test the hypothesis that the relationship between socio-economic deprivation and adenocarcinoma was less strong than for other subtypes. In males all specific histological subtypes except adenocarcinoma declined in incidence. Squamous cell carcinoma remained the most common specific subtype and large cell carcinoma the least common. In females squamous cell carcinoma was initially most common, but its incidence declined slightly and that for adenocarcinoma increased. In both sexes the overall age-standardised incidence rate of lung cancer increased with increasing deprivation. However, these trends were less strong for adenocarcinoma than for the other subtypes in both males (p < 0.001) and females (p = 0.003). The temporal trends and distribution of histological subtypes of lung cancer in males and females are similar to that reported from other western populations. In both males and females, adenocarcinoma was less strongly related to deprivation than other subtypes. This may be because its development is less strongly linked to individual smoking history.
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DOI：
10.1002/ssu.2980090203
发表时间：
1993-03-01
期刊：
SEMINARS IN SURGICAL ONCOLOGY
影响因子：
--
作者：
KABAT, GC
通讯作者：
KABAT, GC
影响因子：
6.4
作者：
Harkness, EF;Brewster, DH;MacFarlane, GJ
通讯作者：
MacFarlane, GJ
影响因子：
10.4
作者：
Wynder, EL;Muscat, JE
通讯作者：
Muscat, JE
DOI：
10.1093/oxfordjournals.pubmed.a024632
发表时间：
1997-09-01
期刊：
JOURNAL OF PUBLIC HEALTH MEDICINE
影响因子：
--
作者：
Pollock, AM;Vickers, N
通讯作者：
Vickers, N
影响因子：
7.7
作者：
Hart, CL;Hole, DJ;Hawthorne, VM
通讯作者：
Hawthorne, VM