Developmental and sensory‐dependent changes of phosphoinositide‐linked metabotropic glutamate receptors
Developmental and sensory‐dependent changes of phosphoinositide‐linked metabotropic glutamate receptors
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磷酸肌醇连接的代谢型谷氨酸受体的发育和感觉依赖性变化
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
N. Daw
中科院分区：
文献类型：
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作者：
S. Reid;C. Romano;Thomas E. Hughes;N. Daw
代谢型谷氨酸受体（mGluRs）可以调节突触传递，有证据表明磷酸肌醇（PI）连接的mGluRs可能参与猫视皮层发育过程中的感觉依赖性可塑性。因此，我们提出了以下问题：PI连锁的mGluR（mGluR 1 α和mGluR 5）在视觉皮层中的位置？这些受体的数量和分布在猫出生后的发育过程中是否会发生变化，这些特征是否依赖于感觉？我们发现，随着年龄的增长，mGluR 1 α的数量减少，而mGluR 1 α的层状分布保持不变。mGluR 5的数量也减少，但mGluR 5的层状分布在发育过程中发生变化。mGluR 5分布变化的模式和时间遵循膝状皮质传入的发展。免疫染色表明，mGluR 1 α的受体减少主要发生在V-VI层，mGluR 5的受体减少主要发生在IV层外侧。暗饲养推迟了mGluR 5的层状变化，并在出生后1.5-6周龄之间产生了mGluR 5水平的增加，但对mGluR 1 α分布或mGluR 1 α数量没有显著影响。这些结果表明mGluR 1 α和mGluR 5参与了皮层发育的不同方面。mGluR 5比mGluR 1 α更可能参与感觉依赖性事件。mGluR数量和眼优势可塑性的关键期之间缺乏发育相关性，这也表明除了mGluR数量之外的其他因素对眼优势可塑性也很重要。J. Comp.神经元389：577-583，1997.© 1997 Wiley利斯公司
Metabotropic glutamate receptors (mGluRs) can modulate synaptic transmission, and there is evidence that phosphoinositide (PI)‐linked mGluRs may be involved in sensory‐dependent plasticity during the development of cat visual cortex. Consequently, we asked the questions: Where are the PI‐linked mGluRs (mGluR1α and mGluR5) in the visual cortex? Does the quantity and distribution of these receptors change in the cat visual cortex during postnatal development, and are these features sensory‐dependent? We found that the quantity of mGluR1α decreases with age, whereas the laminar distribution of mGluR1α remains the same. Quantity of mGluR5 also decreases, but the laminar distribution of mGluR5 changes during development. The pattern and timing of the mGluR5 change in distribution follow the development of geniculocortical afferents. Immunostaining indicates that reduction of receptor occurs mainly in layers V–VI for mGluR1α and outside layer IV for mGluR5. Dark‐rearing postpones the laminar change of mGluR5 and produces an increased level of mGluR5 between postnatal 1.5–6 weeks of age but has no significant effect on the mGluR1α distribution or the mGluR1α quantity. These results suggest that mGluR1α and mGluR5 are involved in different aspects of cortical development. The mGluR5 is more likely to be involved in sensory‐dependent events than mGluR1α. The lack of developmental correlation between mGluR quantities and the critical period for ocular dominance plasticity also suggests that other factors besides mGluR quantities are important for ocular dominance plasticity. J. Comp. Neurol. 389:577–583, 1997. © 1997 Wiley‐Liss, Inc.
DOI：
10.1016/0165-3806(91)90001-y
发表时间：
1991-02-22
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
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作者：
MOWER, GD
通讯作者：
MOWER, GD