Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation.
Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation.
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DOI：
10.1016/j.bbrc.2013.02.077
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发表时间：
2013-03-29
影响因子：
3.1
通讯作者：
Bae, Yoe-Sik
中科院分区：
文献类型：
--
作者：
Lee, Ha Young;Kim, Sang Doo;Baek, Suk-Hwan;Choi, Joon Hyuk;Cho, Kyung-Hyun;Zabel, Brian A.;Bae, Yoe-Sik
Elevated levels of serum amyloid A (SAA) is a risk factor for cardiovascular diseases, however, the role of SAA in the pathophysiology of atherosclerosis remains unclear. Here we show that SAA induced macrophage foam cell formation. SAA-stimulated foam cell formation was mediated by c-jun N-terminal kinase (JNK) signaling. Moreover, both SAA and SAA-conjugated high density lipoprotein stimulated the expression of the important scavenger receptor lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) via nuclear factor-κB (NF-κB). A LOX1 antagonist carrageenan significantly blocked SAA-induced foam cell formation, indicating that SAA promotes foam cell formation via LOX1 expression. Our findings therefore suggest that SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis.
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DOI：
10.1084/jem.20031237
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyle SE;O'Connell RM;Miranda GA;Vaidya SA;Chow EK;Liu PT;Suzuki S;Suzuki N;Modlin RL;Yeh WC;Lane TF;Cheng G
通讯作者：
Cheng G
DOI：
10.1016/j.bbrc.2005.03.069
发表时间：
2005-05-13
影响因子：
3.1
作者：
Lee, HY;Kim, MK;Bae, YS
通讯作者：
Bae, YS
影响因子：
5.4
作者：
Jijon, HB;Madsen, KL;Jobin, C
通讯作者：
Jobin, C
影响因子：
56.9
作者：
Johnson, GL;Lapadat, R
通讯作者：
Lapadat, R
影响因子：
6.5
作者：
Han, JM;Jeong, TS;Cho, KH
通讯作者：
Cho, KH