Roles of the complement system in alcohol-induced liver disease.
Roles of the complement system in alcohol-induced liver disease.
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补体系统在酒精性肝病中的作用
DOI：
10.3350/cmh.2020.0094
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发表时间：
2020-10
影响因子：
8.9
通讯作者：
He S
中科院分区：
文献类型：
--
作者：
Zhou Y;Yuan G;Zhong F;He S
酒精性肝病（ALD）是一种复杂的疾病，其疾病谱范围从脂肪变性到脂肪性肝炎、肝硬化和肝细胞癌。虽然ALD的发病机制还不完全清楚，目前还没有有效的药物可用于ALD，一些证据表明，补体激活和氧化应激在ALD的发病机制中起着至关重要的作用。补体激活可以调节ROS的产生，影响ALD中的氧化应激。在ALD中精确调节补体系统可能是延缓甚至逆转疾病进展并同时促进肝损伤修复的合理而新颖的途径。本文就近年来的研究进展作一简要综述，重点介绍补体和氧化应激介导的转移RNA衍生片段在ALD发病机制中的作用，以期为ALD的治疗提供新的思路。
Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.
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DOI：
10.2119/molmed.2010.00149
发表时间：
2011-03
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Ehrnthaller C;Ignatius A;Gebhard F;Huber-Lang M
通讯作者：
Huber-Lang M
影响因子：
7.5
作者：
Deng Y;Zhao H;Zhou J;Yan L;Wang G;China HepB-Related Fibrosis Assessment Research Group
通讯作者：
China HepB-Related Fibrosis Assessment Research Group
影响因子：
2.4
作者：
Behairy, Behairy E.;El-Mashad, Ghada M.;Sira, Mostafa M.
通讯作者：
Sira, Mostafa M.
影响因子：
4.4
作者：
Bykov, Igor;Junnikkala, Sami;Meri, Seppo
通讯作者：
Meri, Seppo
影响因子：
3.7
作者：
Ferrín G;Rodríguez-Perálvarez M;Aguilar-Melero P;Ranchal I;Llamoza C;Linares CI;González-Rubio S;Muntané J;Briceño J;López-Cillero P;Montero-Álvarez JL;de la Mata M
通讯作者：
de la Mata M