Binding energy and the activation of hormone receptors.
Binding energy and the activation of hormone receptors.
复制标题
结合能和激素受体的激活。
DOI：
10.1016/0006-2952(80)90214-2
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发表时间：
1980
影响因子：
5.8
通讯作者：
T. Franklin
中科院分区：
文献类型：
--
作者：
T. Franklin
许多理论已经被提出来解释激素和药理学受体及其特定配体之间相互作用的本质。然而，除了缺乏对结合相互作用和受体激活的精确分子细节的了解之外，对激动剂功效的性质及其对单个激动剂分子结构的依赖性仍然缺乏了解。在本文中，我希望提请注意Jencks[1]对结合能和酶催化这一主题的精彩评述对受体理论的影响。在我看来，Jencks为解释底物特异性和酶效率提供的概念与受体现象学的一些问题直接相关。
Many theories have been advanced to explain the nature of the interactions between hormonal and pharmacological receptors and their specific ligands. However, in addition to an absence of knowledge of the precise molecular details of the binding interactions and the activation of receptors, there is still a lack of understanding of the nature of agonist efficacy and its dependence upon the molecular structure of individual agonists. In this paper I wish to draw attention to the implications for receptor theory of a masterly review by Jencks [l] on the subject of binding energy and enzymic catalysis. In my view, the concepts provided by Jencks for the explanation of substrate specificity and enzymic efficiency have a direct relevance to some of the problems of receptor phenomenonology.
影响因子：
2.9
作者：
BEECE, D;EISENSTEIN, L;YUE, KT
通讯作者：
YUE, KT
[3H]乙酰胆碱和[3H]氨基甲酰胆碱与鱼雷突触后膜结合的动力学：胆碱能受体的缓慢构象转变。
影响因子：
2.9
作者：
Boyd,ND;Cohen,JB
通讯作者：
Cohen,JB