Altered skin elastic fibers in hypothyroid myxedema and pretibial myxedema.
Altered skin elastic fibers in hypothyroid myxedema and pretibial myxedema.
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甲状腺功能减退粘液性水肿和胫前粘液性水肿中皮肤弹性纤维的改变。
DOI：
10.1001/archinte.1985.00360010153024
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发表时间：
1985
影响因子：
--
通讯作者：
J. Dietrich
中科院分区：
文献类型：
--
作者：
L. Matsuoka;J. Wortsman;J. Uitto;K. Hashimoto;C. Kupchella;A. Eng;J. Dietrich
弹性纤维占真皮体积的2%，负责正常的皮肤弹性。我们研究了皮肤弹性成分的紊乱作为粘液水肿皮肤弹性降低的机制。皮肤活检标本来自甲状腺疾病患者和年龄、性别和活检部位相匹配的正常受试者。弹性纤维浓度，确定Verhoeff-van Gieson染色切片的计算机形态测定分析，甲状腺功能减退症和胫骨前粘液水肿显着低于正常。弹性蛋白浓度降低不是糖胺聚糖浸润的结果。粘液水肿皮肤的超微结构研究显示弹性纤维直径的变化很大，微纤维减少。粘液性水肿（甲状腺功能减退和胫前）与真皮弹性纤维的定量和定性缺陷相关。
Elastic fibers account for 2% of dermal volume and are responsible for normal skin resiliency. We investigated a disorder of the dermal elastic component as the mechanism for the decreased elasticity of skin in myxedema. Skin biopsy specimens were obtained from patients with thyroid diseases and normal subjects matched for age, sex, and biopsy location. Elastic fiber concentration, determined by computerized morphometric analysis of Verhoeff-van Gieson-stained sections, was significantly lower than normal in hypothyroid and pretibial myxedema. The decreased elastin concentration was not a consequence of the glycosaminoglycan infiltration. Ultrastructural studies of myxedematous skin showed wide variability of elastic fiber diameter and decreased microfibrils. Myxedema (hypothyroid and pretibial) is consistently associated with quantitative and qualitative defects of dermal elastic fibers.
甲状腺激素对人皮肤成纤维细胞糖胺聚糖积累的影响。
影响因子：
4.8
作者：
Smith,TJ;Horwitz,AL;Refetoff,S
通讯作者：
Refetoff,S
人体皮肤中的弹性纤维：通过计算机数字图像分析对弹性纤维进行定量，并通过锁链素的放射免疫测定法测定弹性蛋白。
DOI：
--
发表时间：
1983
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Uitto,J;Paul,JL;Brockley,K;Pearce,RH;Clark,JG
通讯作者：
Clark,JG
影响因子：
6.5
作者：
BRAVERMAN, IM;FONFERKO, E
通讯作者：
FONFERKO, E