Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.
Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.
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植物雌激素，邻苯二甲酸酯和苯酚的尿生物标志物的试点研究。
DOI：
10.1289/ehp.9488
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发表时间：
2007-01
影响因子：
10.4
通讯作者：
Calafat AM
中科院分区：
文献类型：
--
作者：
Wolff MS;Teitelbaum SL;Windham G;Pinney SM;Britton JA;Chelimo C;Godbold J;Biro F;Kushi LH;Pfeiffer CM;Calafat AM
在美国儿童中使用尿液中的暴露生物标记物来测量激素活性环境因子。然而，人们对它们在种族、年龄、性别和地理上的差异知之甚少，也没有新开发的生物标志物的数据。我们的目标是描述女性青春期发育研究中相关的、普遍的暴露。在对来自纽约市、纽约州、辛辛那提、俄亥俄州和北加州的90名女孩进行的一项初步研究中，我们测量了25种尿液分析物，代表了来自三个化学家族的22种不同的物质：植物雌激素、邻苯二甲酸盐和酚类。暴露主要来自饮食和家庭或个人护理产品。参与者代表四个种族/族裔群体（亚洲人、黑人、西班牙人、白人），平均年龄为7.77岁。大多数分析物可在bb0.94%的样品中检测到。各科中位浓度最高的是肠内酯（298 μg/L）、邻苯二甲酸一乙酯（MEP; 83.2 μg/L）和二苯甲酮-3 （BP3; 14.7 μg/L）。以前很少或没有关于四种代谢物的数据报道：邻苯二甲酸单（2-乙基-5-羧基戊基）酯、三氯生、双酚A （BPA）和BP3；样品中检出率为67 ~ 100%，中位数为1.8 ~ 53.2 μg/L。多因素调整后，体重指数< 85个参考百分位的女孩的肠内酯和双酚a两种分析物高于高于或等于85个参考百分位的女孩。三种邻苯二甲酸酯代谢物因种族/民族而异[MEP，邻苯二甲酸单（2-乙基己基）酯和邻苯二甲酸单3-羧基丙酯]。在年轻女孩中可以检测到广泛的激素活性暴露生物标志物，并且这些生物标志物在年轻女孩中是可变的，在几种分析物中发现了高浓度（100 μg/L）。它们因可能与发展有关的特征而异。
Hormonally active environmental agents have been measured among U.S. children using exposure biomarkers in urine. However, little is known about their variation by race, age, sex, and geography, and no data exist for newly developed biomarkers. Our goal was to characterize relevant, prevalent exposures for a study of female pubertal development. In a pilot study among 90 girls from New York City, New York, Cincinnati, Ohio, and northern California, we measured 25 urinary analytes representing 22 separate agents from three chemical families: phytoestrogens, phthalates, and phenols. Exposures occur chiefly from the diet and from household or personal care products. Participants represented four racial/ethnic groups (Asian, black, Hispanic, white), with mean age of 7.77 years. Most analytes were detectable in > 94% of samples. The highest median concentrations for individual analytes in each family were for enterolactone (298 μg/L), monoethylphthalate (MEP; 83.2 μg/L), and benzophenone-3 (BP3; 14.7 μg/L). Few or no data have been reported previously for four metabolites: mono(2-ethyl-5-carboxypentyl) phthalate, triclosan, bisphenol A (BPA), and BP3; these were detected in 67–100% of samples with medians of 1.8–53.2 μg/L. After multivariate adjustment, two analytes, enterolactone and BPA, were higher among girls with body mass index < 85th reference percentile than those at or above the 85th percentile. Three phthalate metabolites differed by race/ethnicity [MEP, mono(2-ethylhexyl) phthalate, and mono-3-carboxypropylphthalate]. A wide spectrum of hormonally active exposure biomarkers were detectable and variable among young girls, with high maximal concentrations (> 1,000 μg/L) found for several analytes. They varied by characteristics that may be relevant to development.
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影响因子：
10.4
作者：
Rajapakse N;Silva E;Kortenkamp A
通讯作者：
Kortenkamp A
影响因子：
7.4
作者：
Kato, K;Silva, MJ;Calafat, AM
通讯作者：
Calafat, AM
影响因子：
--
作者：
Koch, HM;Preuss, R;Angerer, J
通讯作者：
Angerer, J
影响因子：
10.4
作者：
Calafat AM;Kuklenyik Z;Reidy JA;Caudill SP;Ekong J;Needham LL
通讯作者：
Needham LL
影响因子：
7.1
作者：
HIMES, JH;DIETZ, WH
通讯作者：
DIETZ, WH