Mediation by nitric oxide of neurogenic relaxation of the urinary bladder neck muscle in sheep.
Mediation by nitric oxide of neurogenic relaxation of the urinary bladder neck muscle in sheep.
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一氧化氮介导绵羊膀胱颈肌肉的神经源性松弛。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
N. McHale
中科院分区：
文献类型：
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作者：
K. Thornbury;M. Hollywood;N. McHale
1. Mechanical recordings were made in vitro from circularly oriented strips of the bladder neck muscle of sheep. In the absence of drugs, electrical field stimulation at frequencies of 0.2‐1 Hz evoked clear‐cut relaxations throughout 1 min stimulation periods, while higher stimulus frequencies (2‐8 Hz) evoked variable responses consisting of relaxation, contraction or a mixture of both. All of the responses were abolished by tetrodotoxin (10(‐6) M). 2. The contractions were reduced by guanethidine (10(‐6) M) and atropine (10(‐6) M), so that in the presence of these drugs clear‐cut relaxations were obtained at 0.2‐8 Hz stimulation, indicating that the relaxations were mediated by non‐adrenergic, non‐cholinergic (NANC) nerves. 3. The NANC relaxations were blocked by L‐NG nitro arginine methyl ester (L‐NAME), an inhibitor of nitric oxide synthesis. The antagonism by L‐NAME was reversed by L‐arginine. 4. Another feature of the NANC relaxation was ‘rebound contraction’ which occurred when the stimulus was switched off. The rebound contraction was also blocked by L‐NAME and restored by L‐arginine. 5. The relaxations and rebound contractions were unaffected by either alpha,beta‐methylene ATP (10(‐5) M) or 2‐methylthio ATP (10(‐5) M). 6. S‐Nitroso‐L‐cysteine, a substance which spontaneously releases NO at physiological pH, mimicked the relaxation and rebound contraction produced by nerve stimulation. 7. It is concluded that nerve‐evoked relaxation of the bladder neck is mediated by NO, or a closely related substance such as S‐nitroso‐L‐cysteine.
一氧化氮合成途径参与犬近端结肠抑制性连接电位。
DOI：
10.1152/ajpgi.1991.260.5.g789
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
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作者：
Dalziel,HH;Thornbury,KD;Ward,SM;Sanders,KM
通讯作者：
Sanders,KM
一氧化氮和亚硝基半胱氨酸模拟犬近端结肠中的非肾上腺素能、非胆碱能超极化。
DOI：
10.1152/ajpgi.1991.261.3.g553
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Thornbury,KD;Ward,SM;Dalziel,HH;Carl,A;Westfall,DP;Sanders,KM
通讯作者：
Sanders,KM
DOI：
10.1016/0006-291x(90)92168-y
发表时间：
1990-07-31
影响因子：
3.1
作者：
IGNARRO, LJ;BUSH, PA;RAJFER, J
通讯作者：
RAJFER, J