Midlife and late-life obesity and the risk of dementia: cardiovascular health study.
Midlife and late-life obesity and the risk of dementia: cardiovascular health study.
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DOI：
10.1001/archneurol.2008.582
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发表时间：
2009-03
影响因子：
--
通讯作者：
Luchsinger, Jose A.
中科院分区：
文献类型：
--
作者：
Fitzpatrick, Annette L.;Kuller, Lewis H.;Lopez, Oscar L.;Diehr, Paula;O'Meara, Ellen S.;Longstreth, W. T., Jr.;Luchsinger, Jose A.
To evaluate associations between mid- and late-life obesity and risk of dementia. Prospective cohort followed 5.4 years from 1992/4 through 1999. Community-dwelling sample in four US sites recruited from Medicare eligibility files. 2,798 adults without dementia, mean age 74.7 years, 59.1% women, participating in the Cardiovascular Health Cognition Study completing a magnetic resonance image, measured for height and weight at baseline (late-life) and self-reporting weight at age 50 (mid-life). Body mass index (BMI) was calculated at both times. Dementia, Alzheimer’s disease (AD) and vascular dementia (VaD) classified by a multidisciplinary committee using standardized criteria. Classification resulted in 480 persons with incident dementia, 245 with AD (no VaD) and 213 with VaD (with or without AD). In evaluations of mid-life obesity, an increased risk of dementia was found for obese (BMI >30) compared to normal (BMI 20-25) persons adjusted for demographics (HR: 1.39, 95% CI: 1.03-1.87) and for caradiovascularl risk factors (HR: 1.36, 95% CI: 0.94-1.95). The risk estimates reversed in assessments of late-life BMI. Underweight persons (BMI < 20) had an increased risk of dementia (HR: 1.62, 95% CI: 1.02-2.64) while being overweight (BMI 25-30) was not associated (HR: 0.92, 95% CI: 0.72-1.18) and being obese reduced the risk of dementia (HR: 0.63, 95% CI: 0.44-0.91) compared to those with normal BMI. These results help explain the “obesity paradox” as differences in dementia risk over time are consistent with physical changes in the trajectory toward disability.
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影响因子：
9.9
作者：
Nourhashémi, F;Deschamps, V;Barberger-Gateau, P
通讯作者：
Barberger-Gateau, P
影响因子：
--
作者：
Kivipelto, M;Ngandu, T;Nissinen, A
通讯作者：
Nissinen, A
影响因子：
--
作者：
Johnson, David K.;Wilkins, Consuelo H.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
9.9
作者：
Luchsinger, JA;Tang, MX;Mayeux, R
通讯作者：
Mayeux, R
影响因子：
9.9
作者：
Knopman, D. S.;Edland, S. D.;Rocca, W. A.
通讯作者：
Rocca, W. A.