Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution.
Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution.
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DOI：
10.3390/ijerph18063258
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发表时间：
2021-03-22
影响因子：
--
通讯作者：
Negin J
中科院分区：
文献类型：
--
作者：
Elbarbary M;Oganesyan A;Honda T;Morgan G;Guo Y;Guo Y;Negin J
空气污染与心血管疾病（CVD）之间有明确的联系，这可能是由全身炎症介导的。本研究评估了长期暴露于环境空气污染与高敏感性C反应蛋白（hs-CRP）之间的联系，研究对象为参加2008-2010年世界卫生组织（WHO）全球老龄化与成人健康研究（SAGE）中国第一轮研究的中国老年人队列（n = 7915）。采用多水平线性和逻辑回归模型来评估颗粒物（PM）和二氧化氮（NO2）与对数转换hs-CRP水平的关系，以及经混杂因素校正的CRP水平得出的心血管疾病风险的比值比。采用基于卫星的空间统计模型估算了每个研究参与者的平均社区室外空气污染物暴露量（空气动力学直径小于等于10 μm的PM （PM10）、小于等于2.5 μm的PM （PM2.5）、小于等于1 μm的PM （PM1）和NO2）。从每个参与者的干血点中提取hs-CRP水平。PM10、PM2.5、PM1和NO2每增加10 μg/m3，血清hs-CRP水平分别升高12.8%（95%可信区间；（CI）： 9.1、16.6）、15.7% （95% CI: 10.9、20.8）、10.2% （95% CI: 7.3、13.2）和11.8% （95% CI: 7.9、15.8）。我们的研究结果表明，空气污染可能是中国老年人全身性炎症增加的一个重要因素。
There is an established association between air pollution and cardiovascular disease (CVD), which is likely to be mediated by systemic inflammation. The present study evaluated links between long-term exposure to ambient air pollution and high-sensitivity C reactive protein (hs-CRP) in an older Chinese adult cohort (n = 7915) enrolled in the World Health Organization (WHO) study on global aging and adult health (SAGE) China Wave 1 in 2008–2010. Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO2) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders. A satellite-based spatial statistical model was applied to estimate the average community exposure to outdoor air pollutants (PM with an aerodynamic diameter of 10 μm or less (PM10), 2.5 μm or less (PM2.5), and 1 μm or less (PM1) and NO2) for each participant of the study. hs-CRP levels were drawn from dried blood spots of each participant. Each 10 μg/m3 increment in PM10, PM2.5, PM1, and NO2 was associated with 12.8% (95% confidence interval; (CI): 9.1, 16.6), 15.7% (95% CI: 10.9, 20.8), 10.2% (95% CI: 7.3, 13.2), and 11.8% (95% CI: 7.9, 15.8) higher serum levels of hs-CRP, respectively. Our findings suggest that air pollution may be an important factor in increasing systemic inflammation in older Chinese adults.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
10.4
作者：
Hennig F;Fuks K;Moebus S;Weinmayr G;Memmesheimer M;Jakobs H;Bröcker-Preuss M;Führer-Sakel D;Möhlenkamp S;Erbel R;Jöckel KH;Hoffmann B;Heinz Nixdorf Recall Study Investigative Group
通讯作者：
Heinz Nixdorf Recall Study Investigative Group
影响因子：
1.6
作者：
Huang WH;Yen TH;Chan MJ;Su YJ
通讯作者：
Su YJ
影响因子：
3.8
作者：
Becker, Susanne;Mundandhara, Sailaja;Madden, Michael
通讯作者：
Madden, Michael