Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer.
Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer.
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DOI：
10.1002/pros.24123
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Sartor O
中科院分区：
文献类型：
--
作者：
Ledet EM;Burgess EF;Sokolova AO;Jaeger EB;Hatton W;Moses M;Miller P;Cotogno P;Layton J;Barata P;Lewis BE;Nakazawa M;Zhu J;Dellinger B;Elrefai S;Nafissi NN;Egan JB;Shore N;McKay RR;Bryce AH;Cheng HH;Antonarakis ES;Sartor O
The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations. African American and Caucasian men with metastatic prostate cancer who had germline testing using multigene panels were used to generate comparisons. Germline genetic results, clinical parameters, and family histories between the two populations were analyzed. A total of 867 patients were included in this retrospective study, including 188 African American and 669 Caucasian patients. There was no significant difference in the likelihood of a pathogenic or likely‐pathogenic variants (PV/LPVs) between African American and Caucasian patients (p = .09). African American patients were more likely to have a variant of unknown significance than Caucasians (odds ratio [OR] = 1.95; p < .0001). BRCA1 PV/LPVs were higher in African Americans (OR = 4.86; p = .04). African American patients were less likely to have a PV/LPV in non‐BRCA DNA repair genes (OR = 0.30; p = .008). Family history of breast (OR = 2.09; p = .002) or ovarian cancer (OR = 2.33; p = .04) predicted PV/LPVs in Caucasians but not African‐Americans. This underscores the limitations of family history in AA men and the importance of personal history to guide germline testing in AA men. In metastatic prostate cancer patients, PV/LPVs of tested genes did not vary by race, BRCA1 PV/LPVs were more common in the African American subset. However, PV/LPVs in non‐BRCA DNA repair genes were less likely to be encountered in African Americans. Family history associated with genetic testing results in Caucasians only.
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影响因子：
30.8
作者：
Yeager, Meredith;Chatterjee, Nilanjan;Ciampa, Julia;Jacobs, Kevin B.;Gonzalez-Bosquet, Jesus;Hayes, Richard B.;Kraft, Peter;Wacholder, Sholom;Orr, Nick;Berndt, Sonja;Yu, Kai;Hutchinson, Amy;Wang, Zhaoming;Amundadottir, Laufey;Feigelson, Heather Spencer;Thun, Michael J.;Diver, W. Ryan;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Schumacher, Fredrick R.;Cancel-Tassin, Geraldine;Cussenot, Olivier;Valeri, Antoine;Andriole, Gerald L.;Crawford, E. David;Haiman, Christopher A.;Henderson, Brian;Kolonel, Laurence;Le Marchand, Loic;Siddiq, Afshan;Riboli, Elio;Key, Timothy J.;Kaaks, Rudolf;Isaacs, William;Isaacs, Sarah;Wiley, Kathleen E.;Gronberg, Henrik;Wiklund, Fredrik;Stattin, Par;Xu, Jianfeng;Zheng, S. Lilly;Sun, Jielin;Vatten, Lars J.;Hveem, Kristian;Kumle, Merethe;Tucker, Margaret;Gerhard, Daniela S.;Hoover, Robert N.;Fraumeni, Joseph F., Jr.;Hunter, David J.;Thomas, Gilles;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.
影响因子：
4
作者：
Southey MC;Goldgar DE;Winqvist R;Pylkäs K;Couch F;Tischkowitz M;Foulkes WD;Dennis J;Michailidou K;van Rensburg EJ;Heikkinen T;Nevanlinna H;Hopper JL;Dörk T;Claes KB;Reis-Filho J;Teo ZL;Radice P;Catucci I;Peterlongo P;Tsimiklis H;Odefrey FA;Dowty JG;Schmidt MK;Broeks A;Hogervorst FB;Verhoef S;Carpenter J;Clarke C;Scott RJ;Fasching PA;Haeberle L;Ekici AB;Beckmann MW;Peto J;Dos-Santos-Silva I;Fletcher O;Johnson N;Bolla MK;Sawyer EJ;Tomlinson I;Kerin MJ;Miller N;Marme F;Burwinkel B;Yang R;Guénel P;Truong T;Menegaux F;Sanchez M;Bojesen S;Nielsen SF;Flyger H;Benitez J;Zamora MP;Perez JI;Menéndez P;Anton-Culver H;Neuhausen S;Ziogas A;Clarke CA;Brenner H;Arndt V;Stegmaier C;Brauch H;Brüning T;Ko YD;Muranen TA;Aittomäki K;Blomqvist C;Bogdanova NV;Antonenkova NN;Lindblom A;Margolin S;Mannermaa A;Kataja V;Kosma VM;Hartikainen JM;Spurdle AB;Investigators K;Australian Ovarian Cancer Study Group;Wauters E;Smeets D;Beuselinck B;Floris G;Chang-Claude J;Rudolph A;Seibold P;Flesch-Janys D;Olson JE;Vachon C;Pankratz VS;McLean C;Haiman CA;Henderson BE;Schumacher F;Le Marchand L;Kristensen V;Alnæs GG;Zheng W;Hunter DJ;Lindstrom S;Hankinson SE;Kraft P;Andrulis I;Knight JA;Glendon G;Mulligan AM;Jukkola-Vuorinen A;Grip M;Kauppila S;Devilee P;Tollenaar RA;Seynaeve C;Hollestelle A;Garcia-Closas M;Figueroa J;Chanock SJ;Lissowska J;Czene K;Darabi H;Eriksson M;Eccles DM;Rafiq S;Tapper WJ;Gerty SM;Hooning MJ;Martens JW;Collée JM;Tilanus-Linthorst M;Hall P;Li J;Brand JS;Humphreys K;Cox A;Reed MW;Luccarini C;Baynes C;Dunning AM;Hamann U;Torres D;Ulmer HU;Rüdiger T;Jakubowska A;Lubinski J;Jaworska K;Durda K;Slager S;Toland AE;Ambrosone CB;Yannoukakos D;Swerdlow A;Ashworth A;Orr N;Jones M;González-Neira A;Pita G;Alonso MR;Álvarez N;Herrero D;Tessier DC;Vincent D;Bacot F;Simard J;Dumont M;Soucy P;Eeles R;Muir K;Wiklund F;Gronberg H;Schleutker J;Nordestgaard BG;Weischer M;Travis RC;Neal D;Donovan JL;Hamdy FC;Khaw KT;Stanford JL;Blot WJ;Thibodeau S;Schaid DJ;Kelley JL;Maier C;Kibel AS;Cybulski C;Cannon-Albright L;Butterbach K;Park J;Kaneva R;Batra J;Teixeira MR;Kote-Jarai Z;Olama AA;Benlloch S;Renner SP;Hartmann A;Hein A;Ruebner M;Lambrechts D;Van Nieuwenhuysen E;Vergote I;Lambretchs S;Doherty JA;Rossing MA;Nickels S;Eilber U;Wang-Gohrke S;Odunsi K;Sucheston-Campbell LE;Friel G;Lurie G;Killeen JL;Wilkens LR;Goodman MT;Runnebaum I;Hillemanns PA;Pelttari LM;Butzow R;Modugno F;Edwards RP;Ness RB;Moysich KB;du Bois A;Heitz F;Harter P;Kommoss S;Karlan BY;Walsh C;Lester J;Jensen A;Kjaer SK;Høgdall E;Peissel B;Bonanni B;Bernard L;Goode EL;Fridley BL;Vierkant RA;Cunningham JM;Larson MC;Fogarty ZC;Kalli KR;Liang D;Lu KH;Hildebrandt MA;Wu X;Levine DA;Dao F;Bisogna M;Berchuck A;Iversen ES;Marks JR;Akushevich L;Cramer DW;Schildkraut J;Terry KL;Poole EM;Stampfer M;Tworoger SS;Bandera EV;Orlow I;Olson SH;Bjorge L;Salvesen HB;van Altena AM;Aben KK;Kiemeney LA;Massuger LF;Pejovic T;Bean Y;Brooks-Wilson A;Kelemen LE;Cook LS;Le ND;Górski B;Gronwald J;Menkiszak J;Høgdall CK;Lundvall L;Nedergaard L;Engelholm SA;Dicks E;Tyrer J;Campbell I;McNeish I;Paul J;Siddiqui N;Glasspool R;Whittemore AS;Rothstein JH;McGuire V;Sieh W;Cai H;Shu XO;Teten RT;Sutphen R;McLaughlin JR;Narod SA;Phelan CM;Monteiro AN;Fenstermacher D;Lin HY;Permuth JB;Sellers TA;Chen YA;Tsai YY;Chen Z;Gentry-Maharaj A;Gayther SA;Ramus SJ;Menon U;Wu AH;Pearce CL;Van Den Berg D;Pike MC;Dansonka-Mieszkowska A;Plisiecka-Halasa J;Moes-Sosnowska J;Kupryjanczyk J;Pharoah PD;Song H;Winship I;Chenevix-Trench G;Giles GG;Tavtigian SV;Easton DF;Milne RL
通讯作者：
Milne RL
影响因子：
13.8
作者：
Fletcher, Sean A.;Marchese, Maya;Quoc-Dien Trinh
通讯作者：
Quoc-Dien Trinh
影响因子：
6.2
作者：
Tsodikov A;Gulati R;de Carvalho TM;Heijnsdijk EAM;Hunter-Merrill RA;Mariotto AB;de Koning HJ;Etzioni R
通讯作者：
Etzioni R
DOI：
10.1158/1055-9965.epi-13-0568
发表时间：
2014-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hjelmborg JB;Scheike T;Holst K;Skytthe A;Penney KL;Graff RE;Pukkala E;Christensen K;Adami HO;Holm NV;Nuttall E;Hansen S;Hartman M;Czene K;Harris JR;Kaprio J;Mucci LA
通讯作者：
Mucci LA