The neurobiology of impulsivity and substance use disorders: implications for treatment.
The neurobiology of impulsivity and substance use disorders: implications for treatment.
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DOI：
10.1111/nyas.13977
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发表时间：
2019-09
影响因子：
5.2
通讯作者：
George TP
中科院分区：
文献类型：
--
作者：
Kozak K;Lucatch AM;Lowe DJE;Balodis IM;MacKillop J;George TP
冲动与物质使用障碍（SUD）密切相关。我们的评论讨论了冲动作为SUD的潜在脆弱性标记，并治疗SUD中共同发生的冲动。冲动性和物质使用障碍（SUD）之间的复杂关系应考虑三个因素：（1）冲动性的特质效应，以降低认知和反应抑制为中心;（2）急性或慢性物质使用对大脑结构和功能的状态效应;（3）遗传和环境因素（例如，年龄和性别）可能影响与SUD相关的冲动行为。主观和客观的措施都用来评估冲动。总之，治疗开发（药理学，行为学和神经生理学）应考虑通过各种措施评估的这些临床相关维度，这对SUD患者的治疗匹配有影响。尽管其异质性，冲动是与SUD相关的标志，可以理解为自下而上和自上而下的神经系统的不平衡。对这些关系的进一步研究可能会导致更有效的SUD治疗。尽管其异质性，冲动性是一个标志物与物质使用障碍（SUD），可以理解为自下而上和自上而下的神经系统的不平衡。我们的评论讨论了多方面的冲动性的建设作为一个潜在的脆弱性标记内的各个阶段的SUD。我们强调理解冲动和成瘾风险的转诊断模型。
Impulsivity is strongly associated with substance use disorders (SUDs). Our review discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co-occurring impulsivity in SUDs. Three factors should be considered for the complex relationship between impulsivity and a substance use disorder (SUD): (1) the trait effect of impulsivity, centering on decreased cognitive and response inhibition; (2) the state effect resulting from either acute or chronic substance use on brain structure and function; and (3) the genetic and environmental factors (e.g., age and sex) may influence impulsive behavior associated with SUDs. Both subjective and objective measures are used to assess impulsivity. Together, treatment developments (pharmacological, behavioral, and neurophysiological) should consider these clinically relevant dimensions assessed by a variety of measures, which have implications for treatment matching in individuals with SUD. Despite its heterogeneity, impulsivity is a marker associated with SUDs and may be understood as an imbalance of bottom-up and top-down neural systems. Further investigation of these relationships may lead to more effective SUD treatments. Despite its heterogeneity, impulsivity is a marker associated with substance used disorders (SUDs) and may be understood as an imbalance of bottom-up and top-down neural systems. Our review discusses the multifaceted construct of impulsivity as an underlying vulnerability marker within the various stages of SUDs. We emphasize a transdiagnostic model for understanding impulsivity and addiction risk.
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影响因子：
3.9
作者：
Bentzley JP;Tomko RL;Gray KM
通讯作者：
Gray KM
DOI：
10.5812/ijhrba.20428
发表时间：
2014-06
影响因子：
--
作者：
Bakhshani NM
通讯作者：
Bakhshani NM
影响因子：
5.1
作者：
Beeli, Gian;Casutt, Gianclaudio;Jaencke, Lutz
通讯作者：
Jaencke, Lutz
DOI：
10.3109/00952990.2011.596979
发表时间：
2011-09
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Covey LS;Hu MC;Green CA;Brigham G;Hurt RD;Adler L;Winhusen T
通讯作者：
Winhusen T
影响因子：
3.9
作者：
Batra, Anil;Collins, Susan E.;Buchkremer, Gerhard
通讯作者：
Buchkremer, Gerhard