Identification of a subset of patients with scleroderma with severe pulmonary and vascular disease by the presence of autoantibodies to centromere and histone.
Identification of a subset of patients with scleroderma with severe pulmonary and vascular disease by the presence of autoantibodies to centromere and histone.
复制标题
通过着丝粒和组蛋白自身抗体的存在来鉴定患有严重肺部和血管疾病的硬皮病患者的子集。
DOI：
10.1136/ard.52.11.780
复制
发表时间：
1993
影响因子：
27.4
通讯作者：
Marvin J. Fritzler
中科院分区：
文献类型：
--
作者：
Liam Martin;J. Pauls;J. P. Ryan;Marvin J. Fritzler
自身抗体在风湿性疾病的研究和治疗中的作用是公认的。本研究的目的是确定系统性风湿性疾病患者血清样本中着丝粒和组蛋白抗体共同出现的临床意义。方法：对1316例连续患者的血清样本进行抗核抗体筛查，并将仅抗着丝粒抗体患者的临床结果与抗着丝粒和组蛋白抗体患者的临床结果进行比较。结果：26例患者有抗着丝粒抗体。14例患者有单独的着丝粒抗体，12例患者有着丝粒和组蛋白抗体。12例有着丝粒和组蛋白抗体的患者中有4例患有弥漫性硬皮病，伴有严重的肺或血管疾病。结论：回顾性研究发现了一部分具有着丝粒和组蛋白抗体的硬皮病患者，他们有严重的肺或血管疾病。随访其他同时具有肺或血管疾病发展抗体的硬皮病患者的临床过程将是有意义的。
OBJECTIVES--The role of autoantibodies in the investigation and management of rheumatic diseases is well recognised. The objective of this study was to determine the clinical significance of the co-occurrence of antibodies to centromere and histone in serum samples from patients investigated for systemic rheumatic diseases. METHODS--Serum samples from 1316 consecutive patients were screened for antinuclear antibodies and the clinical findings in patients with antibodies to centromere alone were compared with those with antibodies to both centromere and histone. RESULTS--Twenty six patients had antibodies to centromere. Fourteen patients had antibodies to centromere alone and 12 patients had antibodies to centromere and histone. Four of the 12 patients with antibodies to centromere and histone had diffuse scleroderma with severe pulmonary or vascular disease. CONCLUSIONS--A subset of patients with scleroderma with antibodies to centromere and histone has been identified retrospectively, who have severe pulmonary or vascular disease. It will be of interest to follow up the clinical course of other patients with scleroderma who have both antibodies for the development of pulmonary or vascular disease.
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DOI：
10.1073/pnas.88.9.3734
发表时间：
1991-05-01
影响因子：
11.1
作者：
PALMER, DK;ODAY, K;MARGOLIS, RL
通讯作者：
MARGOLIS, RL
评论：新生儿红斑狼疮。
影响因子：
--
作者：
Provost,TT
通讯作者：
Provost,TT
进行性系统性硬化症和系统性红斑狼疮有家族性发生。
DOI：
--
发表时间：
1984
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Flores,RH;Stevens,MB;Arnett,FC
通讯作者：
Arnett,FC
影响因子：
5.3
作者：
PALMER, DK;MARGOLIS, RL
通讯作者：
MARGOLIS, RL