Clinical characteristics of rectal cancer patients with neoadjuvant chemoradiotherapy: a nationwide population-based cohort study in South Korea.
Clinical characteristics of rectal cancer patients with neoadjuvant chemoradiotherapy: a nationwide population-based cohort study in South Korea.
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DOI：
10.4174/astr.2021.100.5.282
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发表时间：
2021-05
影响因子：
1.4
通讯作者：
Min BW
中科院分区：
文献类型：
--
作者：
Bong JW;Ju Y;Seo J;Lee JA;Kang SH;Lee SI;Min BW
新辅助放化疗已被接受为II-III期直肠癌的标准治疗。本研究旨在评价韩国直肠癌患者接受新辅助放化疗的临床特点及其对总生存期（OS）的影响。从韩国国家质量评估项目数据库中回顾性分析了2014年至2016年接受根治性直肠癌切除术的患者。患者分为术前手术组和新辅助放化疗组。我们评估了与新辅助放化疗相关的因素及其对OS的影响。采用治疗加权的逆概率来解释亚组之间的基线差异。6141例患者分为术前手术组（n = 4237）和新辅助放化疗组（n = 1904）。新辅助放化疗更常用于男性、直肠癌中癌和年轻患者。在新辅助放化疗组中，年龄、体重过轻、病理分期是发生OS的重要危险因素，而男性、肿瘤大小、临床分期与OS无关。调整后，新辅助放化疗组的OS跟随同病理分期的前期手术组的OS。男性和肿瘤水平与直肠癌新辅助放化疗患者的OS无关。接受新辅助放化疗的患者的OS由其病理分期决定，而与临床分期无关。
Neoadjuvant chemoradiotherapy has been accepted as a standard treatment for stage II–III rectal cancer. This study aimed to evaluate the clinical characteristics of patients who underwent neoadjuvant chemoradiotherapy for rectal cancer and effects on overall survival (OS) of neoadjuvant chemoradiotherapy in South Korea. Patients who underwent curative resection for rectal cancer from 2014 to 2016 were retrospectively reviewed from the database of the National Quality Assessment program in South Korea. Patients were categorized into the upfront surgery group and neoadjuvant chemoradiotherapy group. We evaluated factors associated with the administration of neoadjuvant chemoradiotherapy and its effects on OS. Inverse probability of treatment weighting was performed to account for baseline differences between subgroups. A total of 6,141 patients were categorized into the upfront surgery group (n = 4,237) and neoadjuvant chemoradiotherapy group (n = 1,904). The neoadjuvant chemoradiotherapy was more frequently administered to male, midrectal cancer, and younger patients. In the neoadjuvant chemoradiotherapy group, old age, underweight, and pathologic stage were significant risk factors of OS, and male sex, the level of tumor and clinical stages were not associated with OS. After adjustment, the OS of the neoadjuvant chemoradiotherapy group followed the OS of the upfront surgery group of the same pathologic stage. Male sex and the level of tumor were not related to the OS of rectal cancer patients with neoadjuvant chemoradiotherapy. The OS of patients who underwent neoadjuvant chemoradiotherapy was decided by their pathologic stages regardless of clinical stages.
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影响因子：
8.8
作者：
Claassen YHM;Vermeer NCA;Iversen LH;van Eycken E;Guren MG;Mroczkowski P;Martling A;Codina Cazador A;Johansson R;Vandendael T;Wibe A;Moller B;Lippert H;Rutten HJT;Portielje JEA;Liefers GJ;Holman FA;van de Velde CJH;Bastiaannet E
通讯作者：
Bastiaannet E
影响因子：
9.2
作者：
Li Y;Wang J;Ma X;Tan L;Yan Y;Xue C;Hui B;Liu R;Ma H;Ren J
通讯作者：
Ren J
影响因子：
10.3
作者：
Delitto, Daniel;George, Thomas J., Jr.;Iqbal, Atif
通讯作者：
Iqbal, Atif
影响因子：
28.4
作者：
Cercek, Andrea;Roxburgh, Campbell S. D.;Weiser, Martin R.
通讯作者：
Weiser, Martin R.
DOI：
10.1016/j.ijrobp.2017.03.008
发表时间：
2017-07-01
影响因子：
7
作者：
Sung, SooYoon;Kim, Sung Hwan;Lee, Jong Hoon
通讯作者：
Lee, Jong Hoon