Epigenetic modifications and diabetic retinopathy.
Epigenetic modifications and diabetic retinopathy.
复制标题
DOI：
10.1155/2013/635284
复制
发表时间：
2013
影响因子：
--
通讯作者：
Mishra M
中科院分区：
文献类型：
--
作者：
Kowluru RA;Santos JM;Mishra M
糖尿病视网膜病变仍然是最令人衰弱的慢性并发症之一，但尽管在该领域进行了广泛的研究，但糖尿病视网膜受损的确切机制仍然不明确。许多代谢途径与其发展有关，与这些途径相关的基因被改变。糖尿病环境也有利于表观遗传学修饰，这可以改变基因表达，而不会永久改变DNA序列。表观遗传学在糖尿病视网膜病变中的作用现在是一个新兴领域，最近的工作表明编码线粒体超氧化物歧化酶（Sod 2）和基质金属蛋白酶-9（MMP-9）的基因被表观遗传修饰，激活表观遗传修饰酶，组蛋白赖氨酸脱甲基酶1（LSD 1）和DNA甲基转移酶增加，并且负责调节核转录因子和VEGF的微小RNA被上调。随着越来越多的证据表明糖尿病视网膜病变中的表观遗传修饰，更好地了解这些修饰有可能确定新的靶点来抑制这种毁灭性的疾病。幸运的是，针对组蛋白修饰，DNA甲基化和miRNA的抑制剂和模拟物现在正在尝试用于癌症和其他慢性疾病，更好地了解表观遗传学在糖尿病视网膜病变中的作用将为其可能用于对抗这种致盲性疾病打开大门。
Diabetic retinopathy remains one of the most debilitating chronic complications, but despite extensive research in the field, the exact mechanism(s) responsible for how retina is damaged in diabetes remains ambiguous. Many metabolic pathways have been implicated in its development, and genes associated with these pathways are altered. Diabetic environment also facilitates epigenetics modifications, which can alter the gene expression without permanent changes in DNA sequence. The role of epigenetics in diabetic retinopathy is now an emerging area, and recent work has shown that genes encoding mitochondrial superoxide dismutase (Sod2) and matrix metalloproteinase-9 (MMP-9) are epigenetically modified, activates of epigenetic modification enzymes, histone lysine demethylase 1 (LSD1), and DNA methyltransferase are increased, and the micro RNAs responsible for regulating nuclear transcriptional factor and VEGF are upregulated. With the growing evidence of epigenetic modifications in diabetic retinopathy, better understanding of these modifications has potential to identify novel targets to inhibit this devastating disease. Fortunately, the inhibitors and mimics targeted towards histone modification, DNA methylation, and miRNAs are now being tried for cancer and other chronic diseases, and better understanding of the role of epigenetics in diabetic retinopathy will open the door for their possible use in combating this blinding disease.
登录
查看更多内容
影响因子：
3.9
作者：
Chung, Sangwoon;Yao, Hongwei;Caito, Samuel;Hwang, Jae-Woong;Arunachalam, Gnanapragasam;Rahman, Irfan
通讯作者：
Rahman, Irfan
影响因子：
3.7
作者：
Champion C;Guianvarc'h D;Sénamaud-Beaufort C;Jurkowska RZ;Jeltsch A;Ponger L;Arimondo PB;Guieysse-Peugeot AL
通讯作者：
Guieysse-Peugeot AL
影响因子：
2.7
作者：
Bell CG;Teschendorff AE;Rakyan VK;Maxwell AP;Beck S;Savage DA
通讯作者：
Savage DA
影响因子：
3.7
作者：
Bonnefond, Amelie;Saulnier, Pierre-Jean;Visvikis-Siest, Sophie
通讯作者：
Visvikis-Siest, Sophie
影响因子：
5.1
作者：
Akçay, T;Dinçer, Y;Ilkova, H
通讯作者：
Ilkova, H