SIZE AND FLUCTUATING ASYMMETRY OF MORPHOMETRIC CHARACTERS IN MICE: THEIR ASSOCIATIONS WITH INBREEDING AND t‐HAPLOTYPE
SIZE AND FLUCTUATING ASYMMETRY OF MORPHOMETRIC CHARACTERS IN MICE: THEIR ASSOCIATIONS WITH INBREEDING AND t‐HAPLOTYPE
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小鼠形态特征的大小和波动不对称性：它们与近交和 t 单倍型的关联
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
W. Potts
中科院分区：
文献类型：
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作者：
L. Leamy;Shawn Meagher;S. Taylor;L. Carroll;W. Potts
波动性不对称性（FA）是一种普遍存在的双侧性状不对称性，常被用来衡量群体发育的不稳定性。FA预计将增加人口受到遗传压力，如近亲繁殖或环境压力，如毒素或寄生虫，虽然结果并不总是一致的。我们测试了在实验室饲养的野生小鼠群体中四个骨骼尺寸特征和下颌骨形状的FA是否更大，并进行了一代近亲繁殖（F = 0.25）与远交组（F= 0.00）。FA没有显着不同的近交和远交组，尽管事实上，这两个群体显着不同的健身条件下的自然种群。据我们所知，这是第一个研究，以评估FA和野生家鼠近亲繁殖之间的关系，我们的一般结论是相反的实验室近交系小鼠及其杂交种的早期工作。两个字符的大小是显着小于在近交系比在远交系，但是，有一个显着的差异，在一个字符（肱骨长度）的左右两侧的正负号近交系和远交系之间。两组中的一些小鼠也是t复合体的杂合或纯合携带者。因为携带这种17号染色体变异的小鼠已知具有降低的适应性，我们还测试了它们是否比携带非t单倍型的小鼠具有更大的FA。从所有四个特征计算的复合FA指数的总体水平实际上在携带t的小鼠中显著更高。这些综合结果表明，FA是不是一个普遍敏感的代理措施健身，但可以与健身减少某些遗传压力。
Abstract Fluctuating asymmetry (FA), a ubiquitous type of asymmetry of bilateral characters, often has been used as a measure of developmental instability in populations. FA is expected to increase in populations subjected to genetic stressors such as inbreeding or environmental stressors such as toxins or parasites, although results have not always been consistent. We tested whether FA in four skeletal size characters and mandible shape was greater in a population of wild‐derived mice reared in the laboratory and subjected to one generation of inbreeding (F = 0.25) versus that in an outbred group (F= 0.00). FA did not significantly differ between the inbred and outbred groups, despite the fact that these two groups differed dramatically in fitness under seminatural population conditions. As far as we know, this is the first study to evaluate the relationship between FA and inbreeding in wild house mice, and our general conclusion is opposite that of earlier work on laboratory inbred strains of mice and their hybrids. Size for two of the characters was significantly less in inbreds than in outbreds, however, and there was a significant difference between inbreds and outbreds in the signed differences of right and left sides in one character (humerus length). Some of the mice in both groups also were heterozygous or homozygous carriers of the t‐complex. Because mice carrying this chromosome 17 variant are known to have reduced fitness, we also tested whether they had greater FA than mice carrying non‐t‐haplotypes. The overall level of a composite FA index calculated from all four characters was in fact significantly higher in the t‐bearing mice. These combined results suggest that FA is not a generally sensitive proxy measure for fitness, but can be associated with fitness reductions for certain genetic stressors.
DOI：
10.1073/pnas.060284797
发表时间：
2000-03-28
影响因子：
11.1
作者：
Meagher, S;Penn, DJ;Potts, WK
通讯作者：
Potts, WK