Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii.
Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii.
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Curtisians A-D，来自蘑菇 Paxillus curtisii 的新型自由基清除剂。
DOI：
10.7164/antibiotics.53.114
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
I. Yoo
中科院分区：
文献类型：
--
作者：
B. Yun;I. K. Lee;J. P. Kim;I. Yoo
在对担子菌子实体提取物中自由基清除剂的研究中，我们从长柄桩菇（Paxilluscurtisii）子实体的甲醇提取物中分离得到4个新的对三联苯类化合物，命名为curtisians A-D。经硅胶柱层析、Sephadex LH-20柱层析、薄层层析、高效液相色谱等分离纯化。其结构为对三联苯，取代基分别为乙酰基、苯甲酰基、苯丁酰基、3-羟基丁酰基和3-乙酰氧基丁酰基。Curtisians A、B、C和D具有抗脂质过氧化作用，IC 50值分别为0.15、0.17、0.24和0.14 μ g/ml。
In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A-D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphenyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50, values of 0.15, 0.17, 0.24 and 0.14 microg/ml, respectively.
氧自由基在成人呼吸窘迫综合征、心肌缺血和再灌注损伤以及脑血管损伤中的作用。
影响因子：
2.1
作者：
Hammond,B;Kontos,HA;Hess,ML
通讯作者：
Hess,ML