Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides.
Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides.
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DOI：
10.3390/nu14193923
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发表时间：
2022-09-22
期刊：
影响因子：
5.9
通讯作者：
Kretzschmar D
中科院分区：
文献类型：
--
作者：
Holvoet H;Long DM;Law A;McClure C;Choi J;Yang L;Marney L;Poeck B;Strauss R;Stevens JF;Maier CS;Soumyanath A;Kretzschmar D
睡茄（WS）提取物已被用于传统医学数千年，以促进健康的衰老和福祉。WS现在在西方国家也被广泛用作营养补充剂，以延长健康寿命并提高对年龄相关变化的适应力，包括睡眠不足和抑郁症。虽然人体试验支持WS的有益作用，但研究设计差异很大。植物材料本质上是复杂的，并且提取物随着植物材料的来源和提取方法而变化很大。商业补充剂可以含有各种其他成分，研究人群的特征也可以不同。为了进行最大限度的控制实验，我们使用了分析其组成和稳定性的植物提取物。然后，我们测试了这些提取物在近交果蝇系，以尽量减少在受控环境中的遗传背景的影响。我们发现WS的水提取物（WSAq）在改善身体健康方面最有效，而乙醇提取物（WSE）改善了老年苍蝇的睡眠。这两种提取物都提供了对抗压力引起的行为变化的弹性。WSE比WSAq含有更高水平的睡茄内酯，这被认为是活性成分。因此，睡茄内酯可能介导睡眠改善，而迄今为止未知的富含WSAq的成分可能介导对健身和压力相关行为的影响。
Withania somnifera (WS) extracts have been used in traditional medicine for millennia to promote healthy aging and wellbeing. WS is now also widely used in Western countries as a nutritional supplement to extend healthspan and increase resilience against age-related changes, including sleep deficits and depression. Although human trials have supported beneficial effects of WS, the study designs have varied widely. Plant material is intrinsically complex, and extracts vary widely with the origin of the plant material and the extraction method. Commercial supplements can contain various other ingredients, and the characteristics of the study population can also be varied. To perform maximally controlled experiments, we used plant extracts analyzed for their composition and stability. We then tested these extracts in an inbred Drosophila line to minimize effects of the genetic background in a controlled environment. We found that a water extract of WS (WSAq) was most potent in improving physical fitness, while an ethanol extract (WSE) improved sleep in aged flies. Both extracts provided resilience against stress-induced behavioral changes. WSE contained higher levels of withanolides, which have been proposed to be active ingredients, than WSAq. Therefore, withanolides may mediate the sleep improvement, whereas so-far-unknown ingredients enriched in WSAq likely mediate the effects on fitness and stress-related behavior.
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DOI：
10.1002/alz.12372
发表时间：
2022-01
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Hampel H;Shaw LM;Aisen P;Chen C;Lleó A;Iwatsubo T;Iwata A;Yamada M;Ikeuchi T;Jia J;Wang H;Teunissen CE;Peskind E;Blennow K;Cummings J;Vergallo A
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影响因子：
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Liscia A
老年人睡眠：规范性变化，睡眠障碍和治疗选择。
影响因子：
3.3
作者：
Gooneratne NS;Vitiello MV
通讯作者：
Vitiello MV
影响因子：
48
作者：
Deshpande, Sonali A.;Carvalho, Gil B.;Amador, Ariadna;Phillips, Angela M.;Hoxha, Sany;Lizotte, Keith J.;Ja, William W.
通讯作者：
Ja, William W.
DOI：
10.1523/jneurosci.0228-12.2012
发表时间：
2012-11-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bolkan BJ;Triphan T;Kretzschmar D
通讯作者：
Kretzschmar D