The role of microRNAs in human liver cancers.

The role of microRNAs in human liver cancers.
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DOI:
10.1053/j.seminoncol.2011.08.001
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发表时间:
2011-12
影响因子:
4
通讯作者:
Patel T
Patel T
中科院分区:
医学3区
文献类型:
--
作者:
Braconi C;Henry JC;Kogure T;Schmittgen T;Patel T

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肝细胞癌(HCC)是一种全球性的原发性肝脏恶性肿瘤。近年来对微小RNA(microRNA,miRNA)在肝癌中的表达和作用的研究为肝癌的发病机制提供了新的视角。此外,靶向特定miRNA的治疗努力正在HCC动物模型中进行评估。miRNA作为疾病生物标志物或预后标志物的潜力正在探索中。在此,我们回顾了miRNA在人HCC中表达的研究,并讨论了有关选定的miRNA在疾病发病机制中的参与和作用,作为生物标志物或作为HCC治疗靶点的最新进展。
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.
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