Seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection among Veterans Affairs healthcare system employees suggests higher risk of infection when exposed to SARS-CoV-2 outside the work environment.
Seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection among Veterans Affairs healthcare system employees suggests higher risk of infection when exposed to SARS-CoV-2 outside the work environment.
复制标题
DOI：
10.1017/ice.2020.1220
复制
发表时间：
2021-04
影响因子：
4.5
通讯作者：
Bradley SF
中科院分区：
文献类型：
--
作者：
Dimcheff DE;Schildhouse RJ;Hausman MS;Vincent BM;Markovitz E;Chensue SW;Deng J;McLeod M;Hagan D;Russell J;Bradley SF
在退伍军人事务部医疗保健系统的员工中评估严重急性呼吸综合征-冠状病毒-2（SARS-CoV-2）IgG抗体的血清阳性率，以评估传播和感染的潜在危险因素。所有员工都被邀请参加问卷调查和血清学调查，以检测SARS-CoV-2抗体，作为全机构质量改进和感染预防计划的一部分，无论临床或非临床职责如何。该计划于二零二零年六月八日至七月八日进行。在2，900名员工中，51%参与了研究，显示SARS-CoV-2血清阳性率为4.9%（1，476人中有72人; 95%CI，3.8%-6.1%）。基于性别、年龄、前线工作人员身份、职称、气溶胶生成程序的性能或在医院内接触2019冠状病毒感染性疾病（COVID-19）的已知患者，抗体的存在没有统计学显著差异。报告在工作之外暴露于已知COVID-19病例的员工的血清阳性率为14.8%（155人中的23人），显著高于未暴露于已知COVID-19病例的员工的3.7%（1，296人中的48人; OR，4.53; 95%CI，2.67-7.68; P < .0001）。值得注意的是，29%的血清反应阳性员工报告没有SARS-CoV-2感染的症状史。在提供直接患者护理的员工和不提供直接患者护理的员工中，SARS-CoV-2血清阳性率没有显着差异，这表明全机构的感染控制措施是有效的。报告在工作之外与COVID-19阳性人员直接接触的员工更有可能感染SARS-CoV-2抗体。员工在工作之外接触SARS-CoV-2可能会将感染引入医院。
The seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) IgG antibody was evaluated among employees of a Veterans Affairs healthcare system to assess potential risk factors for transmission and infection. All employees were invited to participate in a questionnaire and serological survey to detect antibodies to SARS-CoV-2 as part of a facility-wide quality improvement and infection prevention initiative regardless of clinical or nonclinical duties. The initiative was conducted from June 8 to July 8, 2020. Of the 2,900 employees, 51% participated in the study, revealing a positive SARS-CoV-2 seroprevalence of 4.9% (72 of 1,476; 95% CI, 3.8%–6.1%). There were no statistically significant differences in the presence of antibody based on gender, age, frontline worker status, job title, performance of aerosol-generating procedures, or exposure to known patients with coronavirus infectious disease 2019 (COVID-19) within the hospital. Employees who reported exposure to a known COVID-19 case outside work had a significantly higher seroprevalence at 14.8% (23 of 155) compared to those who did not 3.7% (48 of 1,296; OR, 4.53; 95% CI, 2.67–7.68; P < .0001). Notably, 29% of seropositive employees reported no history of symptoms for SARS-CoV-2 infection. The seroprevalence of SARS-CoV-2 among employees was not significantly different among those who provided direct patient care and those who did not, suggesting that facility-wide infection control measures were effective. Employees who reported direct personal contact with COVID-19–positive persons outside work were more likely to have SARS-CoV-2 antibodies. Employee exposure to SARS-CoV-2 outside work may introduce infection into hospitals.
登录
查看更多内容
影响因子：
82.9
作者：
Xu, Xin;Sun, Jian;Hou, Fan Fan
通讯作者：
Hou, Fan Fan
影响因子：
28.2
作者：
Chen, Yuxin;Tong, Xin;Wu, Chao
通讯作者：
Wu, Chao
影响因子：
8.8
作者：
Jaaskelainen, A. J.;Kuivanen, S.;Lappalainen, M.
通讯作者：
Lappalainen, M.
影响因子：
9.4
作者：
Bryan, Andrew;Pepper, Gregory;Greninger, Alexander L.
通讯作者：
Greninger, Alexander L.