Antibody seroprevalence in the epicenter Wuhan, Hubei, and six selected provinces after containment of the first epidemic wave of COVID-19 in China.
Antibody seroprevalence in the epicenter Wuhan, Hubei, and six selected provinces after containment of the first epidemic wave of COVID-19 in China.
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中国第一波COVID-19疫情得到遏制后，震中湖北武汉和六个选定省份的抗体血清阳性率。
DOI：
10.1016/j.lanwpc.2021.100094
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Gao GF
中科院分区：
文献类型：
--
作者：
Li Z;Guan X;Mao N;Luo H;Qin Y;He N;Zhu Z;Yu J;Li Y;Liu J;An Z;Gao W;Wang X;Sun X;Song T;Yang X;Wu M;Wu X;Yao W;Peng Z;Sun J;Wang L;Guo Q;Xiang N;Liu J;Zhang B;Su X;Rodewald L;Li L;Xu W;Shen H;Feng Z;Gao GF
为应对COVID-19疫情，中国实施了遏制措施，以阻止SARS-CoV-2传播。在第一波流行后，我们进行了基于人群的血清学调查，以确定感染程度、感染的危险因素和中和抗体水平，以评估随机抽样人群中的真实的感染情况。我们采用多阶段分层整群随机抽样策略，在三个地区进行血清学调查-武汉，武汉以外的湖北省，以及根据COVID-19发病率和遏制策略选择的六个省份。参与者是在流行病期间在调查地区居住超过14天的1岁以上的自愿个体。各省通过两种侧流免疫分析法和一种磁化学发光酶免疫分析法筛查血清SARS-CoV-2特异性IgM、IgG和总抗体;阳性样品通过微量中和试验验证。我们招募了34，857名参与者（总应答率为92%）; 427人通过微量中和试验呈阳性。武汉市加权阳性率最高（4.43%，95%CI = 3.48%~ 5.62%），其次为湖北（湖北除外）（0.44%，95%CI= 0.26%~ 0.76%），其余省份（<0.1%）。居住在武汉（调整后的比值比aOR=13·70，95%CI= 7·91-23·75）、接触COVID-19患者（aOR=7·35，95%CI=5·05-10·69）和年龄超过40岁（aOR=1·36，95%CI=1·07-1·72）与SARS-CoV-2感染显著相关。在血清阳性者中，101例（24%）报告了症状，中和抗体滴度的几何平均值高于326例（76%）无症状者（30± 2.4 vs 15± 2.1，p<0.001）。从武汉到外围省份的整体感染程度较低，血清阳性率梯度陡峭，为中国成功遏制第一波COVID-19疫情提供了证据。SARS-CoV-2感染基本上没有症状，这强调了主动发现病例和物理距离的重要性。事实上，中国的所有人口仍然对SARS-CoV-2易感;需要接种疫苗以获得长期保护。本研究得到了科技部（2020 YFC 0846900）和国家自然科学基金（82041026、82041027、82041028、82041029、82041030、82041032、82041033）的资助。
China implemented containment measures to stop SARS-CoV-2 transmission in response to the COVID-19 epidemic. After the first epidemic wave, we conducted population-based serological surveys to determine extent of infection, risk factors for infection, and neutralization antibody levels to assess the real infections in the random sampled population. We used a multistage, stratified cluster random sampling strategy to conduct serological surveys in three areas - Wuhan, Hubei Province outside Wuhan, and six provinces selected on COVID-19 incidence and containment strategy. Participants were consenting individuals >1 year old who resided in the survey area >14 days during the epidemic. Provinces screened sera for SARS-CoV-2-specific IgM, IgG, and total antibody by two lateral flow immunoassays and one magnetic chemiluminescence enzyme immunoassay; positive samples were verified by micro-neutralization assay. We enrolled 34,857 participants (overall response rate, 92%); 427 were positive by micro-neutralization assay. Wuhan had the highest weighted seroprevalence (4•43%, 95% confidence interval [95%CI]=3•48%-5•62%), followed by Hubei-ex-Wuhan (0•44%, 95%CI=0•26%-0•76%), and the other provinces (<0•1%). Living in Wuhan (adjusted odds ratio aOR=13•70, 95%CI= 7•91–23•75), contact with COVID-19 patients (aOR=7•35, 95%CI=5•05–10•69), and age over 40 (aOR=1•36, 95%CI=1•07–1•72) were significantly associated with SARS-CoV-2 infection. Among seropositives, 101 (24%) reported symptoms and had higher geometric mean neutralizing antibody titers than among the 326 (76%) without symptoms (30±2•4 vs 15±2•1, p<0•001). The low overall extent of infection and steep gradient of seropositivity from Wuhan to the outer provinces provide evidence supporting the success of containment of the first wave of COVID-19 in China. SARS-CoV-2 infection was largely asymptomatic, emphasizing the importance of active case finding and physical distancing. Virtually the entire population of China remains susceptible to SARS-CoV-2; vaccination will be needed for long-term protection. This study was supported by the Ministry of Science and Technology (2020YFC0846900) and the National Natural Science Foundation of China (82041026, 82041027, 82041028, 82041029, 82041030, 82041032, 82041033).
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.1007/s10096-020-04092-3
发表时间：
2021-05
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
Gutiérrez-Cobos A;Gómez de Frutos S;Domingo García D;Navarro Lara E;Yarci Carrión A;Fontán García-Rodrigo L;Fraile Torres AM;Cardeñoso Domingo L
通讯作者：
Cardeñoso Domingo L
影响因子：
6.4
作者：
Cai, Xue-fei;Chen, Juan;Wang, De-qiang
通讯作者：
Wang, De-qiang
影响因子：
4.7
作者：
National Health Commission Of The People's Republic Of China
通讯作者：
National Health Commission Of The People's Republic Of China
影响因子：
4.7
作者：
Tan W;Niu P;Zhao X;Pan Y;Zhang Y;Chen L;Zhao L;Wang Y;Wang D;Han J;Gao GF;Huang C;Xu W;Wu G
通讯作者：
Wu G