Abnormal Cerebrovascular Reactivity and Functional Connectivity Caused by White Matter Hyperintensity Contribute to Cognitive Decline.
Abnormal Cerebrovascular Reactivity and Functional Connectivity Caused by White Matter Hyperintensity Contribute to Cognitive Decline.
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DOI：
10.3389/fnins.2022.807585
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发表时间：
2022
影响因子：
4.3
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Yang D;Qin R;Chu L;Xu H;Ni L;Ma J;Shao P;Huang L;Zhang B;Zhang M;Xu Y
本研究旨在探讨脑血管反应性受损(CVR)和功能连接异常(FC)与白质高强度(WMH)相关性认知功能减退的关系。共招募233名WMH受试者，按Fazekas视觉评定量表分为WMH-I组(106例)、WMH-II组(72例)和WMH-III组(55例)。所有参与者都接受了神经心理测试和多模式磁共振扫描，包括3D-T1和静息状态功能磁共振成像(Rs-fMRI)。进一步探讨了CVR图和Fc图的变化。WMH负荷越高的受试者，左侧枕内侧回(MOG)的CVR越低。以MOG为种子的FC分析显示，随着WMH的加重，左侧脑岛、左侧顶下小叶和丘脑的FC发生异常变化。在调整了年龄、性别和教育年限后，系列中介分析显示，脑室周围白质高强度间接导致较差的简易智力状态检查分数(间接影响：β=−0.1248，95%CI：−0.4689，−0188)，较差的蒙特利尔认知评估分数(间接影响：β=−0.1436，95%CI：−0.4584，−0.0292)，以及较长的连线测验A(间接影响：β=0.1837，95%CI：0.0069，0.8273)次，特别是由于左侧MOG的CVR较低，而左侧岛叶-MOG的Fc较高。左侧MOG的CVR下降和左侧岛叶-MOG的Fc异常是WMH进展导致的一般认知(MMSE和MoCA)和信息加工速度(TMT-A)较差的原因。在WMH患者中，左侧MOG可能作为一种连接，通过与左侧岛叶皮质区域的连接参与认知偏向的加工。
This study aimed to investigate the relationships of impaired cerebrovascular reactivity (CVR) and abnormal functional connectivity (FC) with white matter hyperintensity (WMH)-related cognitive decline. A total of 233 WMH subjects were recruited and categorized into WMH-I (n = 106), WMH-II (n = 72), and WMH-III (n = 55) groups according to Fazekas visual rating scale. All participants underwent neuropsychological tests and multimodal MRI scans, including 3D-T1, and resting-state functional magnetic resonance imaging (rs-fMRI). The alterations of CVR maps and FC were further explored. Subjects with a higher WMH burden displayed a lower CVR in the left medial occipital gyrus (MOG). The FC analysis using MOG as a seed revealed that the FC of the left insula, left inferior parietal lobule, and thalamus changed abnormally as WMH aggravated. After adjusting for age, gender, and education years, the serial mediation analysis revealed that periventricular white matter hyperintensity contributes indirectly to poorer Mini-Mental State Examination (MMSE) scores (indirect effect: β = −0.1248, 95% CI: −0.4689, −0188), poorer Montreal Cognitive Assessment (MoCA) (indirect effect: β = −0.1436, 95% CI: −0.4584, −0.0292) scores, and longer trail making tests A (TMT-A) (indirect effect: β = 0.1837, 95% CI: 0.0069, 0.8273) times, specifically due to the lower CVR of the left MOG and the higher FC of the left insula-MOG. The CVR decline of the left MOG and the abnormal FC of the left insula-MOG attributed to WMH progression were responsible for the poor general cognition (MMSE and MoCA) and information processing speed (TMT-A). The left MOG may act as a connection, which is involved in the processing of cognitive biases by connecting with the left insula-cortical regions in WMH individuals.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
4.7
作者：
Ihara M;Tomimoto H
通讯作者：
Tomimoto H
DOI：
10.1016/j.jstrokecerebrovasdis.2017.08.015
发表时间：
2018-01-01
影响因子：
2.5
作者：
Ryan, Clodagh M.;Battisti-Charbonney, Anne;Venkatraghavan, Lashmi
通讯作者：
Venkatraghavan, Lashmi
影响因子：
3.5
作者：
Sam, K.;Crawley, A. P.;Mikulis, D. J.
通讯作者：
Mikulis, D. J.
影响因子：
4
作者：
Buratti, Laura;Balestrini, Simona;Silvestrini, Mauro
通讯作者：
Silvestrini, Mauro