Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function.
Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function.
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DOI：
10.1007/s40620-020-00934-7
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发表时间：
2021-06
影响因子：
3.4
通讯作者：
Poppelaars F
中科院分区：
文献类型：
--
作者：
Faria B;Gaya da Costa M;Lima C;Willems L;Brandwijk R;Berger SP;Daha MR;Pestana M;Seelen MA;Poppelaars F
各种研究报告了补体调节剂在腹膜透析（PD）期间预防间皮损伤的重要性。然而，由于缺乏容易进入腹膜的途径，其评估在临床实践中受到限制。最近，已经描述了补体调节蛋白CD 59（sCD 59）的可溶形式。因此，我们的目的是研究sCD 59在PD中的作用。通过ELISA（Hycult; HK 374 -02）测定了48例PD患者、41例血液透析患者、15例慢性肾病非透析患者和14例健康对照者的血浆sCD 59。此外，还评估了腹膜透析液中的sCD 59和sC 5 b-9。所有患者的腹膜透析液中均可检测到sCD 59和sC 5 b-9，且两者之间存在轻微相关性（r = 0.27，P = 0.06）。PD患者的血浆sCD 59水平显著高于慢性肾病患者和健康对照组，但与血液透析患者无差异。在随访期间，19%的PD患者发生腹膜衰竭，27%的PD患者发生残余肾功能丧失。在校正模型中，透析液（HR 3.44，95% CI 1.04-11.40，P = 0.04）和血浆（HR 1.08，95% CI 1.01-1.17，P = 0.04）中sCD 59水平升高与腹膜衰竭的发生独立相关。血浆sCD 59水平升高也与残余肾功能丧失相关（HR 1.10，95% CI 1.04-1.17，P < 0.001）。我们的研究表明，sCD 59有可能作为一种生物标志物，以预测腹膜功能和残余肾功能的丧失在PD，从而提供了一种工具，以改善患者的管理。在线版本包含补充材料，可通过10.1007/s40620-020-00934-7获得。
Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its assessment, however, is limited in clinical practice due to the lack of easy access to the peritoneal membrane. Recently, a soluble form of the complement regulatory protein CD59 (sCD59) has been described. We therefore aimed to investigate the role of sCD59 in PD. Plasma sCD59 was measured in 48 PD patients, 41 hemodialysis patients, 15 non-dialysis patients with chronic kidney disease and 14 healthy controls by ELISA (Hycult; HK374-02). Additionally, sCD59 and sC5b-9 were assessed in the peritoneal dialysate. sCD59 and sC5b-9 were detectable in the peritoneal dialysate of all patients, and marginally correlated (r = 0.27, P = 0.06). Plasma sCD59 levels were significantly higher in PD patients than in patients with chronic kidney disease and healthy controls, but did not differ from hemodialysis patients. During follow-up, 19% of PD patients developed peritoneal membrane failure and 27% of PD patients developed loss of residual renal function. In adjusted models, increased sCD59 levels in the dialysate (HR 3.44, 95% CI 1.04–11.40, P = 0.04) and in plasma (HR 1.08, 95% CI 1.01–1.17, P = 0.04) were independently associated with the occurrence of peritoneal membrane failure. Higher plasma levels of sCD59 were also associated with loss of residual renal function (HR 1.10, 95% CI 1.04–1.17, P < 0.001). Our study suggests that sCD59 has potential as a biomarker to predict peritoneal membrane function and loss of residual renal function in PD, thereby offering a tool to improve patient management. The online version contains supplementary material available at 10.1007/s40620-020-00934-7.
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影响因子：
7.3
作者：
Faria, Bernardo;da Costa, Mariana Gaya;Seelen, Marc A.
通讯作者：
Seelen, Marc A.
影响因子：
15.9
作者：
Brasoveanu, LI;Fonsatti, E;Maio, M
通讯作者：
Maio, M
影响因子：
12.8
作者：
Qin, Xuebin;Hu, Weiguo;Song, Wenping;Grubissich, Luciano;Hu, Xuemei;Wu, Gongxiong;Ferris, Sean;Dobarro, Martin;Halperin, Jose A.
通讯作者：
Halperin, Jose A.
影响因子：
7.4
作者：
Poppelaars F;Gaya da Costa M;Berger SP;Assa S;Meter-Arkema AH;Daha MR;van Son WJ;Franssen CF;Seelen MA
通讯作者：
Seelen MA
影响因子：
6.1
作者：
Chung, SH;Heimbürger, O;Lindholm, B
通讯作者：
Lindholm, B