Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential.
Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential.
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DOI：
10.1016/j.actbio.2012.05.031
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发表时间：
2012-09
影响因子：
9.7
通讯作者：
Tay, Franklin R.
中科院分区：
文献类型：
--
作者：
Gong, Shi-qiang;Niu, Li-na;Kemp, Lisa K.;Yiu, Cynthia K. Y.;Ryou, Heonjune;Qi, Yi-pin;Blizzard, John D.;Nikonov, Sergey;Brackett, Martha G.;Messer, Regina L. W.;Wu, Christine D.;Mao, Jing;Brister, L. Bryan;Rueggeberg, Frederick A.;Arola, Dwayne D.;Pashley, David H.;Tay, Franklin R.
设计抗菌聚合物以增强医疗保健问题并将环境问题降至最低是一项具有基础和实际意义的重要努力。硅烷基季铵盐官能化甲基丙烯酸酯(QAMS)是一种采用溶胶-凝胶法合成的抗菌大分子单体，这些化合物具有灵活的Si-O-Si键。本文介绍了一种部分水解型QAMS与双GMA共聚的方法。结果表明，该甲基丙烯酸酯树脂具有良好的力学性能，转化率高，聚合收缩小。以变形链球菌(ATCC 36558)、奈氏放线菌(ATCC 12104)和白色念珠菌(ATCC 90028)为生物膜，研究了该树脂对接触杀灭微生物的活性。水化后机械性能的改善提供了概念验证，即QAMS包含的树脂通过水诱导聚合树脂基质中的有机改性硅酸盐(Ormosil)相的缩合而显示出自我修复潜力。
Design of antimicrobial polymers for enhancing healthcare issues and minimizing environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially-hydrolyzed QAMS copolymerized with bis-GMA is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. Kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.
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