Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in Han Chinese.
Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in Han Chinese.
复制标题
四种淋巴毒素-α基因多态性与汉族冠状动脉疾病风险的基于单倍型的关联。
DOI：
10.1620/tjem.224.119
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Wei Jin 金玮
中科院分区：
文献类型：
--
作者：
Yan Liu;Haihui Sheng;Lin Lu;Zhijun Wu;Qiujin Chen;Huasheng Xiao;Wei Jin 金玮
Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, has been implicated in the pathogenesis of coronary atherosclerosis. Meanwhile, association of some single nucleotide polymorphisms (SNPs) of LTA gene with coronary artery disease (CAD) has been evaluated; however, the results are irreproducible. We therefore investigated the relationship between four SNPs of LTA gene and CAD in Han Chinese: G+10A (rs1800683, 5'-untranslated region), A+80C (rs2239704, 5'-untranslated region), T+496C (Cys13Arg, rs2229094, exon 2), and C+804A (Thr26Asn, rs1041981, exon 3). Genotyping was performed in 438 CAD patients and 330 healthy controls. Single-locus analysis showed that the genotype and allele frequencies of G+10A polymorphism exhibited marginal differences between CAD patients and controls, although no statistical significance was observed after the Bonferroni correction. Logistic regression analysis revealed that GG genotype of G+10A polymorphism was significantly associated with the risk of CAD under the dominant mode, whereas no significant association was detected between A+80C polymorphism and CAD. In contrast, individuals carrying TT or TC genotype of T+496C polymorphism showed a decreased CAD risk relative to those with CC genotype under the recessive mode. Likewise, CC genotype of C+804A polymorphism was associated with a protective effect on CAD under the dominant mode. Further, in haplotype analysis, the haplotype G-C-T-C (in order of rs1800683, rs2239704, rs2229094 and rs1041981) was significantly associated with a decreased risk of CAD after assigning the most common haplotype A-C-T-A as a reference. In conclusion, we show a protective effect of the haplotype G-C-T-C on the occurrence of CAD, suggesting the involvement of LTA in CAD pathogenesis.
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DOI：
10.1111/j.0954-6820.1986.tb13951.x
发表时间：
2009-04
期刊：
Acta medica Scandinavica. Supplementum
影响因子：
--
作者：
G. Bondjers;S. Olofsson;A. Fager;O. Wiklund
通讯作者：
G. Bondjers;S. Olofsson;A. Fager;O. Wiklund
影响因子：
2.8
作者：
Hanxiang Gao;Zheng Zhang;Jin Zhang;N. Zhao;Qiang Li;M. Bai
通讯作者：
Hanxiang Gao;Zheng Zhang;Jin Zhang;N. Zhao;Qiang Li;M. Bai
影响因子：
4.5
作者：
Clarke R;Xu P;Bennett D;Lewington S;Zondervan K;Parish S;Palmer A;Clark S;Cardon L;Peto R;Lathrop M;Collins R;International Study of Infarct Survival (ISIS) Collaborators
通讯作者：
International Study of Infarct Survival (ISIS) Collaborators
影响因子：
6.8
作者：
Rasouli, Mehdi;Kiasari, Asadollah Mohseni
通讯作者：
Kiasari, Asadollah Mohseni
影响因子：
64.8
作者：
Ozaki, K;Inoue, K;Tanaka, T
通讯作者：
Tanaka, T