Widely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival.
Widely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival.
复制标题
DOI：
10.1002/dvg.20679
复制
发表时间：
2010-12
期刊：
影响因子：
1.5
通讯作者：
Zhang, Wenzheng
中科院分区：
文献类型：
--
作者：
Zhang, Zhijing;Huang, Le;Reisenauer, Mary Rose;Wu, Hongyu;Chen, Lihe;Zhang, Yujin;Xia, Yang;Zhang, Wenzheng
关键词：
As a putative transcription factor, Af17 may play a role in multiple signaling pathways. However, the Af17 expression profile during development and in adult tissues remains largely uncharacterized. The importance of Af17 function in embryogenesis, hematopoiesis and animal survival has never been addressed before. Here we report the generation of the first Af17 mutant mouse model, and characterization of the Af17 temporal and spatial expression profile in various embryonic stages and adult tissues by X-gal staining, in situ hybridization and RT-PCR. Af17 expression is detected in specific cell populations in all stages and in multiple tissues examined. In situ hybridization yielded a consistent Af17 expression pattern by X-gal staining. Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical, behavioral or hematopoietic abnormalities. Thus, our studies describe the generation of the first Af17 mutant mouse model, provide the first developmental profile of Af17 expression, and reveal that Af17 may be dispensable for normal embryogenesis, hematopoiesis, and animal survival.
登录
查看更多内容
影响因子：
4.8
作者：
Reisenauer, Mary Rose;Anderson, Marc;Zhang, Wenzheng
通讯作者：
Zhang, Wenzheng
影响因子：
5.5
作者：
Zhang, WZ;Xia, XF;Kone, BC
通讯作者：
Kone, BC
影响因子：
1.2
作者：
Vogel, Tanja;Gruss, Peter
通讯作者：
Gruss, Peter
影响因子：
64.5
作者：
Okada, Y;Feng, Q;Zhang, Y
通讯作者：
Zhang, Y
DOI：
10.1016/s0167-4781(98)00226-7
发表时间：
1998-12-22
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Linder, B;Jones, LK;Saha, V
通讯作者：
Saha, V