Growth factors and adipocytokines in prepubertal children born small for gestational age: relation to insulin resistance.
Growth factors and adipocytokines in prepubertal children born small for gestational age: relation to insulin resistance.
复制标题
DOI：
10.2337/dc08-1570
复制
发表时间：
2009-04
期刊：
影响因子：
16.2
通讯作者：
Andronikou SK
中科院分区：
文献类型：
--
作者：
Challa AS;Evagelidou EN;Cholevas VI;Kiortsis DN;Giapros VI;Drougia AA;Andronikou SK
本研究的目的是测试出生小于胎龄 (SGA) 是否会对脂联素和瘦素水平以及与胰岛素敏感性相关的 IGF 系统产生影响，同时考虑到生长受限的严重程度。对 57 名 4-10 岁儿童的脂联素、瘦素、空腹血糖、空腹胰岛素 (IF)、稳态模型评估胰岛素抵抗指数 (HOMA-IR)、IGF-1、游离 IGF-1、IGFBP-1 和 -3、总胆固醇、HDL 胆固醇、LDL 胆固醇和甘油三酯的血清水平进行了评估。其中，32 例出生时体型适合胎龄 (AGA)，25 例出生时为 SGA（14 例处于 <3% 百分位，11 例处于 3-10% 百分位）。 SGA 3-10% 儿童在青春期前就已经出现胰岛素抵抗（IF 39.6 ± 16.8 vs. 27 ± 12 pmol/l，P < 0.01，SGA 与 AGA 儿童的 HOMA-IR 1.4 ± 0.6 vs. 0.95 ± 0.42，P < 0.05）。他们的 IGF-1 和 IGFBP-3 浓度显着低于 AGA 儿童（SGA 与 AGA 儿童分别为 160.4 ± 66.2 与 207 ± 66.8 mg/l，P < 0.05；SGA 为 2.3 ± 0.4 与 3.51 ± 1.21 mg/l，P < 0.01）。 SGA<3%的儿童的脂联素（15.6±5.7mg/l，P<0.05）和IGFBP-1水平（113.5±33.9μg/l，P<0.05）高于AGA儿童（分别为11.3±6.6mg/l和90.8±24.2μg/l），而IGF-1和IGF-1水平较低。 IGFBP-3 浓度（162.6 ± 68.4 μg/l，P < 0.05 和 2.4 ± 0.7 mg/l，P < 0.01）。他们的腰围也显着降低（P < 0.05）。各组之间的瘦素水平没有差异，但在合并的 SGA 组中发现与 IGFBP-1 呈负相关（r = -0.55，P < 0.01）。子宫内生长受限似乎会影响青春期前的 IGF 轴，其严重程度会影响胰岛素敏感性。
The aim of this study was to test whether being born small for gestational age (SGA) has an impact on adiponectin and leptin levels and the IGF system in relation to insulin sensitivity, taking into consideration the severity of growth restriction. Serum levels of adiponectin, leptin, fasting glucose, fasting insulin (IF), the homeostasis model assessment insulin resistance index (HOMA-IR), IGF-1, free IGF-1, IGF-binding protein (IGFBP)-1 and -3, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were evaluated in 57 children at age 4–10 years. Of these, 32 had been born appropriate size for gestational age (AGA) and 25 SGA (14 in the <3rd percentile and 11 in the 3rd–10th percentile). The SGA 3rd–10th percentile children were already insulin resistant at prepubertal age (IF 39.6 ± 16.8 vs. 27 ± 12 pmol/l, P < 0.01, and HOMA-IR 1.4 ± 0.6 vs. 0.95 ± 0.42 in SGA vs. AGA children, P < 0.05). Their IGF-1 and IGFBP-3 concentrations were significantly lower than those in AGA children (160.4 ± 66.2 vs. 207 ± 66.8 μg/l, P < 0.05 and 2.3 ± 0.4 vs. 3.51 ± 1.21 mg/l in SGA vs. AGA children, P < 0.01). The SGA <3rd percentile children had higher adiponectin (15.6 ± 5.7 mg/l, P < 0.05) and IGFBP-1 levels (113.5 ± 33.9 μg/l, P < 0.05) than AGA children (11.3 ± 6.6 mg/l and 90.8 ± 24.2 μg/l, respectively) and lower IGF-1 and IGFBP-3 concentrations (162.6 ± 68.4 μg/l, P < 0.05 and 2.4 ± 0.7 mg/l, P < 0.01). They also had significantly lower waist circumference (P < 0.05). Leptin levels did not differ among groups, but an inverse correlation with IGFBP-1 (r = −0.55, P < 0.01) was found in the pooled SGA group. Intrauterine growth restriction appears to affect the IGF axis at prepubertal age, and its severity plays a role in insulin sensitivity.
登录
查看更多内容
影响因子：
7.7
作者：
COHEN, RM;ABPLANALP, WA
通讯作者：
ABPLANALP, WA
影响因子：
4
作者：
Hong, Y;Brismar, K;deFaire, U
通讯作者：
deFaire, U
影响因子：
5.8
作者：
Liew, CF;Wise, SD;Lee, KO
通讯作者：
Lee, KO
影响因子：
8.2
作者：
Ong, KK;Petry, CJ;Dunger, DB
通讯作者：
Dunger, DB
影响因子：
5.8
作者：
Weyer, C;Funahashi, T;Tataranni, PA
通讯作者：
Tataranni, PA