Cell-based therapies for Huntington's disease.
Cell-based therapies for Huntington's disease.
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DOI：
10.1016/j.drudis.2014.02.012
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发表时间：
2014-07
影响因子：
7.4
通讯作者：
Chan, Anthony W. S.
中科院分区：
文献类型：
--
作者：
Chen, Yiju;Carter, Richard L.;Cho, In K.;Chan, Anthony W. S.
Cell-based therapies are a viable option for the long-term treatment of Huntington’s disease (HD), which is characterized by progressive neurodegeneration predominately in the striatum and cortex. Current research focuses on genetic suppression of the mutant huntingtin (mHTT) gene and cell replacement therapy of the lost cells in the HD [LM1]. As we discuss here, the recent development of induced pluripotent stem (iPS) cells technology demonstrated the potential of cell-based therapy in rodent models. It was shown that iPSCs were capable of differentiating into lost neurons in HD and stem cell grafts can improve motor deficiency in HD rodent models. Altogether, these findings have shown great promise for developing the foundation of the cell-based therapy.
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影响因子：
14.9
作者：
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通讯作者：
Corey DR
DOI：
10.1073/pnas.0808488105
发表时间：
2008-10-28
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