Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands.
Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands.
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DOI：
10.1038/s41467-020-19481-7
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发表时间：
2020-11-12
影响因子：
16.6
通讯作者：
Zaaijer HL
中科院分区：
文献类型：
--
作者：
Slot E;Hogema BM;Reusken CBEM;Reimerink JH;Molier M;Karregat JHM;IJlst J;Novotný VMJ;van Lier RAW;Zaaijer HL
世界正在抗击持续不断的新冠肺炎 (COVID-19) 大流行，医疗保健系统、社会和经济受到前所未有的影响。目前尚不清楚有多少人在不知情的情况下感染了致病冠状病毒（SARS-CoV-2）并且没有症状。因此，报告的 COVID-19 病例并不能反映疫情的真实规模。在这里，我们使用高性能免疫测定法展示了荷兰（荷兰是一个受影响严重的国家）健康成年人群中 SARS-CoV-2 抗体的流行情况和分布。我们的结果表明，疫情爆发一个月后（i）荷兰的血清阳性率为 2.7%，地区差异很大；（ii）受灾最严重的地区的血清阳性率高达 9.5%；（iii）整个年龄组（18-72 岁）的血清阳性率与性别无关；（iv）抗体在年轻人（18-30 岁）中出现的频率明显更高。我们的研究提供了有关在实行社交距离的国家中接触 SARS-CoV-2 程度的重要信息。荷兰是一个受新冠肺炎 (COVID-19) 大流行影响严重的国家。在这项研究中，Slot、Hogema 及其同事报告了疫情爆发一个月后 SARS-CoV-2 血清阳性率较低的情况，并提供了在广泛的非药物干预措施到位时按地区和年龄组划分的病毒暴露情况的见解。
The world is combating an ongoing COVID-19 pandemic with health-care systems, society and economies impacted in an unprecedented way. It is unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly and are asymptomatic. Therefore, reported COVID-19 cases do not reflect the true scale of outbreak. Here we present the prevalence and distribution of antibodies to SARS-CoV-2 in a healthy adult population of the Netherlands, which is a highly affected country, using a high-performance immunoassay. Our results indicate that one month into the outbreak (i) the seroprevalence in the Netherlands was 2.7% with substantial regional variation, (ii) the hardest-hit areas showed a seroprevalence of up to 9.5%, (iii) the seroprevalence was sex-independent throughout age groups (18–72 years), and (iv) antibodies were significantly more often present in younger people (18–30 years). Our study provides vital information on the extent of exposure to SARS-CoV-2 in a country where social distancing is in place. The Netherlands is a country highly affected by the COVID-19 pandemic. In this study, Slot, Hogema and colleagues report a low SARS-CoV-2 seroprevalence one month into the outbreak and provide insights into virus exposure by region and age group when widespread non-pharmaceutical interventions are in place.
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影响因子：
5
作者：
Meyer B;Drosten C;Müller MA
通讯作者：
Müller MA
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.1192/j.eurpsy.2020.89
发表时间：
2020-09-28
期刊：
European psychiatry : the journal of the Association of European Psychiatrists
影响因子：
--
作者：
Fiorillo A;Sampogna G;Giallonardo V;Del Vecchio V;Luciano M;Albert U;Carmassi C;Carrà G;Cirulli F;Dell'Osso B;Nanni MG;Pompili M;Sani G;Tortorella A;Volpe U
通讯作者：
Volpe U
影响因子：
30.3
作者：
Ilinykh, Philipp A.;Huang, Kai;Bukreyev, Alexander
通讯作者：
Bukreyev, Alexander
影响因子：
8.8
作者：
Korth, Johannes;Wilde, Benjamin;Herrmann, Anke
通讯作者：
Herrmann, Anke