The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis.
The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis.
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DOI：
10.1002/clc.23465
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发表时间：
2020-12
影响因子：
2.7
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Luo L;Fu M;Li Y;Hu S;Luo J;Chen Z;Yu J;Li W;Dong R;Yang Y;Tu L;Xu X
本研究评估了2019冠状病毒病（COVID-19）患者的基础合并症和心脏损伤与预后之间的关系。潜在的合并症和心脏损伤可能与COVID-19患者的预后相关。从2019年12月至2020年7月在PubMed、EMBASE、Web of science和The科克伦图书馆进行了系统检索。使用比值比（OR）和95%置信区间（95% CI）估计COVID-19患者（有或无重度类型）或COVID-19患者的幸存者与非幸存者中合并症和心脏损伤的概率。本分析共纳入124项研究。在合并症的COVID-19患者中观察到更高的严重风险。高血压患者的汇总结果（OR 2.57，95% CI：2.12 - 3.11），糖尿病（OR 2.54，95% CI：1.89 - 3.41），心血管疾病（OR 3.86，95% CI：2.70 - 5.52），慢性阻塞性肺疾病（OR 2.71，95% CI：1.98 - 3.70）、慢性肾脏疾病（OR 2.20，95% CI：1.27 - 3.80）和癌症（OR 2.42，95% CI：1.81 - 3.22）。所有合并症的死亡风险均较高。此外，重症组中急性心脏损伤的患病率高于非重症组，并且急性心脏损伤与院内死亡风险增加相关。合并症和急性心脏损伤与COVID-19患者的不良预后密切相关。有必要持续监测COVID-19患者器官损伤和关注合并症的相关临床指标。
The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID‐19) patients was assessed in this study. The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID‐19 patients. A systematic search was conducted in PubMed, EMBASE, Web of science, and The Cochrane library from December 2019 to July 2020. The odds ratio (OR) and 95% confidence intervals (95% CI) were used to estimate the probability of comorbidities and cardiac injury in COVID‐19 patients with or without severe type, or in survivors vs nonsurvivors of COVID‐19 patients. A total of 124 studies were included in this analysis. A higher risk for severity was observed in COVID‐19 patients with comorbidities. The pooled result in patients with hypertension (OR 2.57, 95% CI: 2.12‐3.11), diabetes (OR 2.54, 95% CI: 1.89‐3.41), cardiovascular diseases (OR 3.86, 95% CI: 2.70‐5.52), chronic obstractive pulmonary disease (OR 2.71, 95% CI: 1.98‐3.70), chronic kidney disease (OR 2.20, 95% CI: 1.27‐3.80), and cancer (OR 2.42, 95% CI: 1.81‐3.22) respectively. All the comorbidities presented a higher risk of mortality. Moreover, the prevalence of acute cardiac injury is higher in severe group than in nonsevere group, and acute cardiac injury is associated with an increased risk for in‐hospital mortality. Comorbidities and acute cardiac injury are closely associated with poor prognosis in COVID‐19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID‐19 patients.
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影响因子：
19
作者：
Colaneri, Marta;Sacchi, Paolo;Bruno, Raffaele
通讯作者：
Bruno, Raffaele
影响因子：
15.1
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影响因子：
3.1
作者：
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通讯作者：
Nayudu, Suresh K.
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
14.2
作者：
Cen, Y.;Chen, X.;Liu, Y. -H.
通讯作者：
Liu, Y. -H.