SARS-CoV-2 infections in children following the full re-opening of schools and the impact of national lockdown: Prospective, national observational cohort surveillance, July-December 2020, England.
SARS-CoV-2 infections in children following the full re-opening of schools and the impact of national lockdown: Prospective, national observational cohort surveillance, July-December 2020, England.
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DOI：
10.1016/j.jinf.2021.02.022
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Ladhani SN
中科院分区：
文献类型：
--
作者：
Mensah AA;Sinnathamby M;Zaidi A;Coughlan L;Simmons R;Ismail SA;Ramsay ME;Saliba V;Ladhani SN
新冠肺炎疫情期间学校重新开学，引发了人们对教职员工和学生、他们的家人以及更广泛社区的安全的担忧。我们监测了学龄儿童中SARS-CoV-2的感染率，并将其与英国学校开学前和开学后的成人感染率进行了比较。英国公共卫生局每天都会收到全国范围内所有SARS-CoV-2检测的电子报告。分析了2020年7月至12月按学年划分的SARS-CoV-2感染率，包括2020年11月全国学校开学期间长达一个月的封锁的影响。SARS-CoV-2感染率在初夏较低，但从8月中旬开始上升，最初在年轻人中，然后是中学和小学适龄儿童，直到2020年9月学校重新开学。学校重新开学后，学龄儿童的病例落后于成人趋势，每周感染率存在很大的年龄梯度。成人与继发(R2=0.96~0.98)、初发(R2=0.93~0.94)和学龄前(R2=0.62~0.85)儿童之间存在较强的区域感染率相关性(P<；0.001)。11月份的封锁与成人感染率的下降有关，一周后，学生病例也随之下降。从2020年11月23日起，成人和儿童病例迅速增加，因为出现了一种更易传播的新的关切变种(VOC-202,012/01；B.1.1.7)。在学龄儿童中，SARS-CoV-2感染遵循与成人相同的趋势，只有在国家实施封锁并保持学校开放后才有所下降。保持较低的社区感染率对于在大流行期间保持学校开放至关重要。
The reopening of schools during the COVID-19 pandemic has raised concern for the safety of staff and students, their families and the wider community. We monitored SARS-CoV-2 infection rates in school-aged children and compared them with adult infection rates before and after schools reopened in England. Public Health England receives daily electronic reports of all SARS-CoV-2 tests nationally. SARS-CoV-2 infection rates by school year from July to December 2020 were analysed, including the effect of a national month-long lockdown whilst keeping schools open in November 2020 SARS-CoV-2 infections rates were low during early summer but started increasing in mid-August, initially in young adults followed by secondary and then primary school-aged children prior to schools reopening in September 2020. Cases in school-aged children lagged behind and followed adult trends after schools reopened, with a strong age gradient in weekly infection rates. There was a strong (P<0.001) correlation in regional infection rates between adults and secondary (R2=0.96–0.98), primary (R2=0.93–0.94) and preschool-aged (R2=0.62–0.85) children. The November lockdown was associated with declines in adult infection rates, followed a week later, by declines in student cases. From 23 November 2020, cases in adults and children increased rapidly following the emergence of a more transmissible novel variant of concern (VOC-202,012/01; B.1.1.7). In school-aged children, SARS-CoV-2 infections followed the same trajectory as adult cases and only declined after national lockdown was implemented whilst keeping schools open. Maintaining low community infection rates is critical for keeping schools open during the pandemic.
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影响因子：
36.4
作者：
Macartney, Kristine;Quinn, Helen E.;Wood, Nicholas
通讯作者：
Wood, Nicholas
影响因子：
19
作者：
Stein-Zamir, Chen;Abramson, Nitza;Miskin, Ian
通讯作者：
Miskin, Ian
DOI：
10.1016/s1473-3099(20)30882-3
发表时间：
2021-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Ismail SA;Saliba V;Lopez Bernal J;Ramsay ME;Ladhani SN
通讯作者：
Ladhani SN
影响因子：
15.8
作者：
Buitrago-Garcia D;Egli-Gany D;Counotte MJ;Hossmann S;Imeri H;Ipekci AM;Salanti G;Low N
通讯作者：
Low N
DOI：
10.2807/1560-7917.es.2020.25.38.2001645
发表时间：
2020-09
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Otte Im Kampe E;Lehfeld AS;Buda S;Buchholz U;Haas W
通讯作者：
Haas W