Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats.
Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats.
复制标题
膳食不饱和脂肪和饱和脂肪对氧化偶氮甲烷诱导的大鼠结肠癌发生的影响。
作者：
M. Sakaguchi;Y. Hiramatsu;H. Takada;M. Yamamura;K. Hioki;K. Saito;M. Yamamoto
研究了饮食中不饱和脂肪和饱和脂肪对化学诱导的雄性冬柳大鼠结肠癌发生的影响。饲喂含5%亚油酸和4.7%硬脂酸+0.3%必需脂肪酸的两种半纯饲料作为饲料脂肪。大鼠皮下注射偶氮甲烷(7.4 mg/kg体重)。每周一次，持续11周，并在最后一次注射致癌物后15周处死。饲喂不饱和脂肪饲料的大鼠结肠癌发病率[100%]显著高于饲喂饱和脂肪饲料的大鼠[2.68+/-1.60(S.D.)]，且组织学恶性分化程度更高[分别为76%，1.79+/-1.59]。对结肠肿瘤和结肠粘膜的脂质分析表明，不饱和脂肪饮食显著改变了结肠粘膜的磷脂脂肪酰基组成，并增加了结肠肿瘤中性脂中花生四烯酸的含量。粘膜脂质成分的改变可能增加了结肠对致癌物的敏感性，花生四烯酸或其代谢产物的过量可能是结肠癌发生的主要因素。这些发现表明，饮食中的不饱和脂肪对结肠癌的发生有很强的致癌作用。
The effects of dietary unsaturated and saturated fats on chemically induced colon carcinogenesis were examined in male Donryu rats. The rats were fed two types of semipurified diets consisting of 5% linoleic acid or 4.7% stearic acid plus 0.3% essential fatty acid as dietary fats. The rats were treated with azoxymethane (7.4 mg/kg body weight) s.c. once a week for 11 weeks and sacrificed 15 weeks after the last injection of the carcinogen. The rats fed unsaturated fat diet demonstrated a significantly higher incidence of colon tumors [100%], more tumors per rat [2.68 +/- 1.60 (S.D.)], and greater malignant differentiation histologically than did those fed saturated fat diet [76%, 1.79 +/- 1.59, respectively]. Lipid analysis of colon tumors and colon mucosa showed that unsaturated fat diet altered the phosphatide fatty acyl composition of colon mucosa markedly and increased the content of arachidonic acid in the neutral lipid of colon tumors. The altered lipid composition of the mucosa may increase the sensitivity of the colon to the carcinogen, and the excess of arachidonic acid or its metabolites may be the primary agents of cocarcinogenesis of colon tumors. These findings suggest that dietary unsaturated fats have potent cocarcinogenic effects on colon carcinogenesis.
Friend 红白血病细胞中的 TPA 抗性：膜脂流动性的作用。
DOI：
10.1016/s0006-291x(81)80106-4
发表时间：
1981
影响因子：
3.1
作者：
Fisher,PB;Cogan,U;Horowitz,AD;Schachter,D;Weinstein,IB
通讯作者：
Weinstein,IB