A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.
A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.
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DOI：
10.1155/2013/180453
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发表时间：
2013
影响因子：
--
通讯作者：
Troncy E
中科院分区：
文献类型：
--
作者：
Moreau M;Pelletier JP;Lussier B;d'Anjou MA;Blond L;Pelletier JM;del Castillo JR;Troncy E
多年来，家犬作为骨关节炎（OA）的模型引起了人们的特别兴趣。在此，我们优化了犬实验性骨关节炎的模型，该模型由颅侧交叉韧带切断诱导。该模型证明了非侵入性补充结果测量的有用性，例如肢体功能的步态分析和结构变化的磁共振成像。建立了功能障碍和结构变化严重程度之间的关系，包括软骨变薄的测量。在自然发生OA的犬模型中，肢体功能的测量具有极好的重测信度。确定了一个标准，以确定临床上有意义的治疗反应，私人拥有的狗进行临床试验。此外，基于加速度计的自发活动持续时间的记录显示出与生物力学肢体功能的强互补一致性。这些模型的翻译潜力，以人类OA条件的强调。临床前试验方案结合了由颅侧交叉韧带横断诱导的实验性OA的犬模型和自然发生的OA的犬模型，为进一步研究疾病改善策略的结构和功能益处提供了机会。最终，将带来对人类临床试验结果的更好预测。
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.
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影响因子：
2.8
作者：
Bae, Won C.;Payanal, Melanie M.;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
5.5
作者：
Anandacoomarasamy, Ananthila;Smith, Garett;March, Lyn
通讯作者：
March, Lyn
影响因子：
27.4
作者：
Boileau, C.;Martel-Pelletier, J.;Pelletier, J-P
通讯作者：
Pelletier, J-P
DOI：
10.1097/01.blo.0000197079.26600.09
发表时间：
2006-01-01
影响因子：
4.2
作者：
Andriacchi, Thomas P.;Briant, Paul L.;Koo, Seungbum
通讯作者：
Koo, Seungbum
影响因子：
7
作者：
d'Anjou, M. -A.;Troncy, E.;Pelletier, J. -P.
通讯作者：
Pelletier, J. -P.