Calcium in red blood cells-a perilous balance.
Calcium in red blood cells-a perilous balance.
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DOI：
10.3390/ijms14059848
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发表时间：
2013-05-08
影响因子：
5.6
通讯作者：
Kaestner L
中科院分区：
文献类型：
--
作者：
Bogdanova A;Makhro A;Wang J;Lipp P;Kaestner L
Ca2+是一种参与调节细胞周期和命运、代谢和结构完整性、运动性和体积的通用信号分子。与其他细胞一样，红细胞（RBC）在从前体细胞分化期间依赖于Ca2+依赖性信号传导。循环人RBC中的细胞内Ca2+水平不仅参与控制生物物理性质如膜组成、体积和流变性质，而且还参与控制生理参数如代谢活性、氧化还原状态和细胞清除。人RBC膜对Ca2+的极低基础渗透性和强大的Ca2+泵将细胞内游离Ca2+水平维持在30和60 nM之间，而血浆Ca2+约为1.8 mM。因此，Ca2+摄取的激活对细胞中的多个过程具有令人印象深刻的影响，使Ca2+成为RBC中的主要调节剂。人红细胞中Ca 2+转运蛋白的功能障碍导致细胞内Ca 2+的过度积累。这与许多病理状态有关，包括镰状细胞病、地中海贫血、磷酸果糖激酶缺乏症和其他形式的遗传性贫血。在解开Ca2+转运途径的分子性质方面的持续进展允许利用Ca2+摄取，避免过早的RBC清除和血栓形成并发症。这篇综述总结了我们目前对红细胞中Ca2+信号传导的认识，强调了这种无机阳离子在红细胞功能和存活中的重要性。
Ca2+ is a universal signalling molecule involved in regulating cell cycle and fate, metabolism and structural integrity, motility and volume. Like other cells, red blood cells (RBCs) rely on Ca2+ dependent signalling during differentiation from precursor cells. Intracellular Ca2+ levels in the circulating human RBCs take part not only in controlling biophysical properties such as membrane composition, volume and rheological properties, but also physiological parameters such as metabolic activity, redox state and cell clearance. Extremely low basal permeability of the human RBC membrane to Ca2+ and a powerful Ca2+ pump maintains intracellular free Ca2+ levels between 30 and 60 nM, whereas blood plasma Ca2+ is approximately 1.8 mM. Thus, activation of Ca2+ uptake has an impressive impact on multiple processes in the cells rendering Ca2+ a master regulator in RBCs. Malfunction of Ca2+ transporters in human RBCs leads to excessive accumulation of Ca2+ within the cells. This is associated with a number of pathological states including sickle cell disease, thalassemia, phosphofructokinase deficiency and other forms of hereditary anaemia. Continuous progress in unravelling the molecular nature of Ca2+ transport pathways allows harnessing Ca2+ uptake, avoiding premature RBC clearance and thrombotic complications. This review summarizes our current knowledge of Ca2+ signalling in RBCs emphasizing the importance of this inorganic cation in RBC function and survival.
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影响因子：
5.5
作者：
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