Synovial class II antigen expression and immune complex formation in rheumatoid arthritis.
Synovial class II antigen expression and immune complex formation in rheumatoid arthritis.
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类风湿关节炎中滑膜 II 类抗原的表达和免疫复合物的形成。
DOI：
10.1111/j.0954-6820.1987.tb09907.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
K. Rubin
中科院分区：
文献类型：
--
作者：
L. Klareskog;R. Holmdahl;C. Nordling;A. Tarkowski;K. Rubin
类风湿关节的局部炎性病变表现出与几种涉及局部T淋巴细胞激活的慢性炎症反应相同的特征。因此，正常滑膜组织中只有少数I1类表达细胞能够向T淋巴细胞提呈抗原(1-5)，而类风湿滑膜组织中含有大量不同类型的I1表达细胞，其中一些细胞具有很高的抗原提呈能力(1-5)。RA局部T淋巴细胞活化与这些滑膜I1类表达细胞接触的证据来源于滑膜T淋巴细胞表达活化标志物的程度高于同一类风湿患者的外周T淋巴细胞(1、6、7)。活化的T淋巴细胞，如存在于RA滑膜中的T淋巴细胞，可能会分泌伽玛-干扰素，并可能分泌其他分子，在先前的I1类阴性细胞(8，9)中诱导I1类抗原的表达。因此，结论是在类风湿关节中存在自我持久的I1类依赖T淋巴细胞激活的条件(1，3，4)，这种类型随后被认为也发生在一些具有可疑自身免疫背景的其他组织特异性炎性病变中(10-14)。
The local inflammatory lesions in rheumatoid joints display characteristics that are shared with several chronic inflammatory reactions that involve local Tlymphocyte activation. Thus, whereas normal synovial tissue only contains a few class I1 expressing cells capable of antigen-presentation to T lymphocytes (1-5), the rheumatoid synovial tissue contains a large number of various class I1 expressing cells, some of which have a high antigen-presenting capacity (1-5). Evidence that a local T lymphocyte activation in RA occurs in contact with these synovial class I1 expressing cells stems from the demonstration that synovial T lymphocytes express activation markers to a greater extent than do peripheral T lymphocytes from the same rheumatoid patients (1, 6, 7). ActivatedTlymphocytes such as those present in the RA synovium may secrete gamma-interferon and possibly other molecules with capacity to induce class I1 antigen expression in previously class I1 negative cells (8, 9). It was therefore concluded that conditions are present in the rheumatoid joint for a self-perpetuating class I1 dependent T lymphocyte activation (1, 3, 4) of a kind that has subsequently been suggested to occur also in a number of other tissue-specific inflammatory lesions with a suspected autoimmune background (10-14).
由对结核分枝杆菌和软骨蛋白聚糖有反应的 T 淋巴细胞克隆诱导的关节炎。
DOI：
10.1073/pnas.82.15.5117
发表时间：
1985
影响因子：
11.1
作者：
vanEden,W;Holoshitz,J;Nevo,Z;Frenkel,A;Klajman,A;Cohen,IR
通讯作者：
Cohen,IR