Role of CD14 in host protection against infections and in metabolism regulation.
Role of CD14 in host protection against infections and in metabolism regulation.
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DOI：
10.3389/fcimb.2013.00032
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发表时间：
2013
影响因子：
5.7
通讯作者：
Granucci F
中科院分区：
文献类型：
--
作者：
Zanoni I;Granucci F
CD 14是一种糖基磷脂酰肌醇（GPI）锚定受体，已知在细胞表面和内体区室中充当几种Toll样受体（TLR）的共受体。CD 14可以由造血和非造血来源的细胞表达为细胞膜或分泌蛋白。虽然CD 14在20多年前就被发现了，但其活性在很大程度上仍有待确定。大多数可用的信息涉及CD 14作为与TLR 4一起工作的共受体的作用，并促进细胞对低剂量脂多糖（LPS）的应答。最近的研究已经强调并从分子上定义了这种模式识别受体（PRR）的许多其他功能。这些功能包括CD 14允许在LPS刺激时激活TLR 4-TRAM-TRIF途径的机制; CD 14激活TLR 4非依赖性信号传导途径的能力，导致NFAT转录因子家族成员的激活，在骨髓细胞中具有重要后果; CD 14对肥胖症易感性条件下细胞代谢的影响。在这篇综述中，我们总结了最近的进展，对先天免疫细胞中的CD 14在响应LPS和CD 14在生理和病理条件下激活的后果所发挥的多重作用的分子定义。
CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14 can be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein. Although CD14 was discovered more than 20 years ago, its activities remain largely to be defined. Most of the information available concerns CD14's role as a co-receptor working with TLR4 and facilitating cellular responses to low doses of lipopolysaccharide (LPS). Recent studies have highlighted and molecularly defined many other functions of this pattern recognition receptor (PRR). These functions include the mechanisms through which CD14 allows the activation of the TLR4-TRAM-TRIF pathway upon LPS stimulation; the capacity of CD14 to transduce a TLR4-independent signaling pathway leading to the activation of NFAT transcription factor family members with important consequences in myeloid cells; the CD14 influence on cell metabolism in conditions predisposing to obesity. In this review, we summarize recent progresses toward the molecular definition of the multiple roles exerted by CD14 in innate immune cells in response to LPS and the consequences of CD14 activation in physiologic and pathologic conditions.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
6.4
作者：
Akira, S;Hoshino, K
通讯作者：
Hoshino, K
影响因子：
3.1
作者：
DUNN, PL;NORTH, RJ
通讯作者：
NORTH, RJ
DOI：
10.1084/jem.20040370
发表时间：
2004-08-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Granucci F;Zanoni I;Pavelka N;Van Dommelen SL;Andoniou CE;Belardelli F;Degli Esposti MA;Ricciardi-Castagnoli P
通讯作者：
Ricciardi-Castagnoli P
DOI：
10.4049/jimmunol.1202446
发表时间：
2013-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kelley SL;Lukk T;Nair SK;Tapping RI
通讯作者：
Tapping RI