Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage - clinical and radiological findings in an ovine animal model.
Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage - clinical and radiological findings in an ovine animal model.
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DOI：
10.1186/2193-1801-2-418
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kalla K
中科院分区：
文献类型：
--
作者：
Daentzer D;Floerkemeier T;Bartsch I;Masalha W;Welke B;Hurschler C;Kauth T;Kaltbeitzel D;Hopmann C;Kujat B;Kalla K
生物可吸收性植入物在脊柱外科中应用并不广泛。本研究在羊动物模型中研究了采用由镁和聚合物（聚-ϵ-caprolactone， PCL）组成的实验性生物可吸收笼与三皮质骨移植作为金标准程序的临床和放射学结果。24只成年羊ACDF分别为C3/4和C5/6，一期采用实验性生物吸收性植入物（镁和PCL），二期采用自体三皮质骨移植。随机分为4组，每组6只。术后3周、6周、12周、24周取颈椎，对各手术节段进行常规x线检查。椎间融合的进展按照3点评分系统进行分类。除术中髂前上棘骨折1例，螺钉松动和下沉2例外，无手术相关并发症。特别是没有观察到血管、神经、伤口愈合或感染问题。根据随访时间，两种椎间融合装置表现出相似的行为，24周后12个运动节段中有10个（83.3%）椎间骨融合和完全关节融合术。在本实验动物研究中使用的生物可吸收镁- pcl笼在临床上没有出现感染或伤口愈合问题等不相容迹象。骨融合的影像学结果在骨笼组和骨移植物组之间具有可比性。
Bioabsorbable implants are not widely used in spine surgery. This study investigated the clinical and radiological findings after anterior cervical discectomy and fusion (ACDF) in an ovine animal model with an experimental bioabsorbable cage consisting of magnesium and polymer (poly-ϵ-caprolactone, PCL) in comparison to a tricortical bone graft as the gold standard procedure. 24 full-grown sheep had ACDF of C3/4 and C5/6 with an experimental bioabsorbable implant (magnesium and PCL) in one level and an autologous tricortical bone graft in the second level. The sheep were divided into 4 groups (6 sheep each). After 3, 6, 12, or 24 weeks postoperatively, the cervical spines were harvested and conventional x-rays of each operated segment were conducted. The progress of interbody fusion was classified according to a three-point scoring system. There were no operation related complications except for one intraoperative fracture of the anterior superior iliac spine and two cases of screw loosening and sinking, respectively. In particular, no vascular, neurologic, wound healing or infectious problems were observed. According to the time of follow-up, both interbody fusion devices showed similar behaviour with increasing intervertebral osseointegration and complete arthrodesis in 10 of 12 (83.3%) motion segments after 24 weeks. The bioabsorbable magnesium-PCL cage used in this experimental animal study showed clinically no signs of incompatibility such as infectious or wound healing problems. The radiographic results regarding the osseointegration are comparable between the cage and the bone graft group.
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影响因子：
4.8
作者：
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通讯作者：
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作者：
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