Controlled release of diclofenac from matrix polymer of chitosan and oxidized konjac glucomannan.
Controlled release of diclofenac from matrix polymer of chitosan and oxidized konjac glucomannan.
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DOI：
10.3390/md9091649
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发表时间：
2011
期刊：
影响因子：
5.4
通讯作者：
Muangsin N
中科院分区：
文献类型：
--
作者：
Korkiatithaweechai S;Umsarika P;Praphairaksit N;Muangsin N
研究了双氯芬酸钠（DFNa）在壳聚糖-氧化葡甘聚糖（CTS-OKG）聚合物膜中的控制释放。魔芋葡甘聚糖（KGM）经高碘酸钠氧化后，通过亚胺键（-C=N-）与壳聚糖（CTS）交联，得到新型的CTS-OKG共聚物。采用傅立叶变换红外光谱（FT-IR）和X射线衍射（XRD）对DFNa负载CTS-OKG聚合物进行了表征。最后，在模拟胃肠液系统中评价DFNa从CTS-OKG聚合物基质的释放曲线，所述模拟胃肠液系统包括在模拟胃液（SGF; pH 1.2）中2小时，然后在模拟肠液（SIF; pH 7.4）中24小时。在室温下制备3小时的1：2：1（w/w/w）比率的CTS：OKG：DFNa得到95.6 ± 0.6的最高%包封效率（EE），并且导致DFNa在SGF（pH 1.2）中的最小释放（在2小时内<1%）和在SIF（pH 7.4）中的显著改善的持续释放，在8小时和24小时内分别释放约6%和19%，比两种商业DFNa制剂Diclosian和Voltaren的释放低约15倍和5倍。该制剂可作为长期肠控释药物模型（至少3天）用于进一步研究。
The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa (<1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days).
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影响因子：
6.1
作者：
Muangsin, N;Prajuabsook, M;Hannongbua, S
通讯作者：
Hannongbua, S
影响因子：
4.6
作者：
Chen, LG;Liu, ZL;Zhuo, RX
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Zhuo, RX
影响因子：
5.8
作者：
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Fell, JT
影响因子：
4.6
作者：
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通讯作者：
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影响因子：
5.8
作者：
González-Rodríguez, ML;Holgado, MA;Fini, A
通讯作者：
Fini, A