microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective.
microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective.
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DOI：
10.3390/ijms232415645
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发表时间：
2022-12-09
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
与大动脉粥样硬化相关的缺血性卒中（IS）是发达国家死亡和残疾的主要原因之一。动脉粥样硬化性颈内动脉狭窄（ICAS）占所有脑缺血病例的20%。目前，动脉粥样硬化的预防和治疗措施旨在控制动脉粥样硬化的危险因素，或对成熟的闭塞性病变进行介入（手术或血管内）治疗。明确缺乏已建立的循环生物标志物，其一旦被调节，可以防止动脉粥样硬化的发展，从而防止颈动脉相关的IS。最近的研究强调，microRNA（miRNA）是新兴的颗粒，可能在这种方法中发挥关键作用。有一些关于小的非编码microRNA的表达与颈动脉斑块的发展和脆弱性之间的关联的研究。然而，数据仍然不一致。此外，所有关于颈动脉粥样硬化斑块的主要研究都是在细胞培养或动物模型上进行的;很少在人类身上进行，而越来越多的证据表明，它不能自动外推到人类的过程。本文就miRNA在颈动脉斑块形成、破裂及脑卒中发生中的作用作一综述。我们讨论了可能用作预后或治疗工具的潜在靶点miRNA。
Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool.
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影响因子：
3.4
作者：
Grosse GM;Derda AA;Stauss RD;Neubert L;Jonigk DD;Kühnel MP;Gabriel MM;Schuppner R;Wilhelmi M;Bär C;Bauersachs J;Schrimpf C;Thum T;Weissenborn K
通讯作者：
Weissenborn K
影响因子：
5.6
作者：
Raskurazhev, Anton A.;Kuznetsova, Polina, I;Shabalina, Alla A.;Tanashyan, Marine M.
通讯作者：
Tanashyan, Marine M.
影响因子：
3.9
作者：
Formanowicz D;Krawczyk JB;Perek B;Lipski D;Tykarski A
通讯作者：
Tykarski A
影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
DOI：
10.3390/diagnostics10121111
发表时间：
2020-12-21
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Vista FP 4th;Ngo MT;Cho SB;Kwak HS;Chong KT
通讯作者：
Chong KT